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SHR Neuro Cancer Cardio Lipid Metab Microb

Hirota, K; Turner, JE; Villa, M; Duarte, JH; Demengeot, J; Steinmetz, OM; Stockinger, B.
Plasticity of T(H)17 cells in Peyer's patches is responsible for the induction of T cell-dependent IgA responses
NAT IMMUNOL. 2013; 14(4): 372-379. Doi: 10.1038/ni.2552 [OPEN ACCESS]
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Co-authors Med Uni Graz: Villa Matteo
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Abstract:: Intestinal Peyer's patches are essential lymphoid organs for the generation of T cell-dependent immunoglobulin A (IgA) for gut homeostasis. Through the use of interleukin 17 (IL-17) fate-reporter mice, we found here that endogenous cells of the T(H)17 subset of helper T cells in lymphoid organs of naive mice 'preferentially' homed to the intestines and were maintained independently of IL-23. In Peyer's patches, such T(H)17 cells acquired a follicular helper T cell (T-FH cell) phenotype and induced the development of IgA-producing germinal center B cells. Mice deficient in TH17 cells failed to generate antigen-specific IgA responses, which provides evidence that T(H)17 cells are the crucial subset required for the production of high-affinity T cell-dependent IgA.