Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
'Sullivan, DO; Stanczak, MA; Villa, M; Uhl, FM; Corrado, M; Geltink, RIK; Sanin, DE; Apostolova, P; Rana, N; Edwards-Hicks, J; Grzes, KM; Kabat, AM; Kyle, RL; Fabri, M; Curtis, JD; Buck, MD; Patterson, AE; Regina, A; Field, CS; Baixauli, F; Puleston, DJ; Pearce, EJ; Zeiser, R; Pearce, EL.
Fever supports CD8+effector T cell responses by mitochondrial translation
P NATL ACAD SCI USA. 2021; 118(25): e2023752118
Doi: 10.1073/pnas.2023752118
Web of Science
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- Co-authors Med Uni Graz
- Villa Matteo
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- Abstract:
- Fever can provide a survival advantage during infection. Metabolic processes are sensitive to environmental conditions, but the effect of fever on T cell metabolism is not well characterized. We show that in activated CD8* T cells, exposure to febrile temperature (39 degrees C) augmented metabolic activity and T cell effector functions, despite having a limited effect on proliferation or activation marker expression. Transcriptional profiling revealed an up-regulation of mitochondrial pathways, which was consistent with increased mass and metabolism observed in T cells exposed to 39 degrees C. Through in vitro and in vivo models, we determined that mitochondrial translation is integral to the enhanced metabolic activity and function of CD8* T cells exposed to febrile temperature. Transiently exposing donor lymphocytes to 39 degrees C prior to infusion in a myeloid leukemia mouse model conferred enhanced therapeutic efficacy, raising the possibility that exposure of T cells to febrile temperatures could have clinical potential.
- Find related publications in this database (Keywords)
- T cell
- metabolism
- immunology
- fever
- mitochondria