Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Benzing, C; Krenzien, F; Mieg, A; Wolfsberger, A; Andreou, A; Nevermann, N; Pelzer, U; Fehrenbach, U; Haiden, LM; Öllinger, R; Schöning, W; Schmelzle, M; Pratschke, J.
A tailored approach in lymph node-positive perihilar cholangiocarcinoma.
Langenbecks Arch Surg. 2021; 406(5): 1499-1509.
Doi: 10.1007/s00423-021-02154-4
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- Co-Autor*innen der Med Uni Graz
- Haiden Lena Marie
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- Abstract:
- PURPOSE: Extended right hepatectomy is associated with wide surgical margins in PHC and often favored for oncological considerations. However, it remains uncertain whether established surgical principles also apply to the subgroup of node-positive patients. The aim of the present study was to define a tailored surgical approach for patients with perihilar cholangiocarcinoma (PHC) and lymph node metastases. METHODS: We reviewed the course of all consecutive patients undergoing major hepatectomy for PHC between 2005 and 2015 at the Department of Surgery, Charité - Universitätsmedizin Berlin. RESULTS: Two hundred and thirty-one patients underwent major hepatectomy for PHC with 1-, 3-, and 5-year overall (OS) and disease-free survival (DFS) rates of 72%, 48%, and 36%, and 60%, 22%, and 12%, respectively. In lymph node-positive patients (n = 109, 47%), extended left hepatectomy was associated with improved OS and DFS, respectively, when compared to extended right hepatectomy (p = 0.008 and p = 0.003). Interestingly, OS and DFS did not differ between R0 and R1 resections in those patients (both p = ns). Patients undergoing extended left hepatectomy were more likely to receive adjuvant chemotherapy (p = 0.022). This is of note as adjuvant chemotherapy, besides grading (p = 0.041), was the only independent prognostic factor in node-positive patients (p=0.002). CONCLUSION: Patients with node-positive PHC might benefit from less aggressive approaches being associated with lower morbidity and a higher chance for adjuvant chemotherapy. Lymph node sampling might help to guide patients to the appropriate surgical approach according to their lymph node status.
- Find related publications in this database (using NLM MeSH Indexing)
- Bile Duct Neoplasms - surgery
- Cholangiocarcinoma - surgery
- Hepatectomy - administration & dosage
- Humans - administration & dosage
- Klatskin Tumor - surgery
- Lymph Nodes - surgery
- Retrospective Studies - administration & dosage
- Survival Rate - administration & dosage
- Treatment Outcome - administration & dosage
- Find related publications in this database (Keywords)
- Lymph node positive perihilar cholangiocarcinoma
- Major hepatectomy
- Long-term survival
- Postoperative complications