Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Johannesson, B; Sattler, S; Semenova, E; Pastore, S; Kennedy-Lydon, TM; Sampson, RD; Schneider, MD; Rosenthal, N; Bilbao, D.
Insulin-like growth factor-1 induces regulatory T cell-mediated suppression of allergic contact dermatitis in mice.
Dis Model Mech. 2014; 7(8): 977-85.
Doi: 10.1242/dmm.015362
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- Führende Autor*innen der Med Uni Graz
- Sattler Susanne
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- Abstract:
- Allergic contact dermatitis (ACD) is triggered by an aberrant hyperinflammatory immune response to innocuous chemical compounds and ranks as the world's most prevalent occupational skin condition. Although a variety of immune effector cells are activated during ACD, regulatory T (Treg) cells are crucial in controlling the resulting inflammation. Insulin-like growth factor-1 (IGF-1) regulates cell proliferation and differentiation and accelerates wound healing and regeneration in several organs including the skin. Recently IGF-1 has also been implicated in protection from autoimmune inflammation by expansion of Treg cells. Here, we demonstrate that ectopic expression of IGF-1 in mouse skin suppresses ACD in a Treg cell-specific manner, increasing the number of Foxp3+ Treg cells in the affected area and stimulating lymphocyte production of the anti-inflammatory cytokine interleukin 10. Similar therapeutic effects can be achieved with systemic or topical delivery of IGF-1, implicating this growth factor as a promising new therapeutic option for the treatment of ACD.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals - administration & dosage
- Dermatitis, Allergic Contact - immunology, pathology
- Ear - pathology
- Forkhead Transcription Factors - metabolism
- Humans - administration & dosage
- Insulin-Like Growth Factor I - metabolism, pharmacology
- Interleukin-10 - metabolism
- Lymphocyte Count - administration & dosage
- Mice, Inbred C57BL - administration & dosage
- Mice, Transgenic - administration & dosage
- Receptor, IGF Type 1 - metabolism
- Skin - drug effects, immunology, pathology
- T-Lymphocytes, Regulatory - drug effects, immunology
- Find related publications in this database (Keywords)
- Insulin-like growth factor-1
- Atopic dermatitis
- Contact hypersensitivity
- Regulatory T cells
- Treg