Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Sattler, S; Smits, HH; Xu, D; Huang, FP.
The evolutionary role of the IL-33/ST2 system in host immune defence.
Arch Immunol Ther Exp (Warsz). 2013; 61(2): 107-17.
Doi: 10.1007/s00005-012-0208-8
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PubMed
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- Führende Autor*innen der Med Uni Graz
- Sattler Susanne
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- Abstract:
- Interleukin (IL)-33 is a recently identified pleiotropic cytokine, which can orchestrate complex innate and adaptive immune responses in immunity and disease. It has been characterized as a cytokine of the IL-1 family and affects a wide range of immune cells by signalling through its receptor ST2L. Accumulating evidence suggests a crucial role of IL-33/ST2 in inducing and modifying host immune responses against a variety of pathogens including parasites, bacteria, viruses and fungi as well as sterile insults of both endogenous and exogenous source. In this review, we endeavour to give a comprehensive overview of the current knowledge about the role of IL-33 and its receptor ST2 in host defence against infections.
- Find related publications in this database (using NLM MeSH Indexing)
- Adaptive Immunity - administration & dosage
- Animals - administration & dosage
- Biological Evolution - administration & dosage
- Host-Pathogen Interactions - immunology
- Humans - administration & dosage
- Immunity, Innate - administration & dosage
- Infections - immunology
- Interleukin-1 - immunology
- Interleukin-1 Receptor-Like 1 Protein - administration & dosage
- Interleukin-33 - administration & dosage
- Interleukins - immunology
- Receptors, Cell Surface - immunology
- Find related publications in this database (Keywords)
- IL-33
- ST2
- Infection
- Infectious disease
- Host defence
- Immune response