Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Sattler, S; Ling, GS; Xu, D; Hussaarts, L; Romaine, A; Zhao, H; Fossati-Jimack, L; Malik, T; Cook, HT; Botto, M; Lau, YL; Smits, HH; Liew, FY; Huang, FP.
IL-10-producing regulatory B cells induced by IL-33 (Breg(IL-33)) effectively attenuate mucosal inflammatory responses in the gut.
J Autoimmun. 2014; 50(100): 107-22.
Doi: 10.1016/j.jaut.2014.01.032
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- Führende Autor*innen der Med Uni Graz
- Sattler Susanne
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- Abstract:
- Regulatory B cells (Breg) have attracted increasing attention for their roles in maintaining peripheral tolerance. Interleukin 33 (IL-33) is a recently identified IL-1 family member, which leads a double-life with both pro- and anti-inflammatory properties. We report here that peritoneal injection of IL-33 exacerbated inflammatory bowel disease in IL-10-deficient (IL-10(-/-)) mice, whereas IL-33-treated IL-10-sufficient (wild type) mice were protected from the disease induction. A phenotypically unconventional subset(s) (CD19(+)CD25(+)CD1d(hi)IgM(hi)CD5(-)CD23(-)Tim-1(-)) of IL-10 producing Breg-like cells (Breg(IL-33)) was identified responsible for the protection. We demonstrated further that Breg(IL-33) isolated from these mice could suppress immune effector cell expansion and functions and, upon adoptive transfer, effectively blocked the development of spontaneous colitis in IL-10(-/-) mice. Our findings indicate an essential protective role, hence therapeutic potential, of Breg(IL-33) against mucosal inflammatory disorders in the gut.
- Find related publications in this database (using NLM MeSH Indexing)
- Adoptive Transfer - administration & dosage
- Animals - administration & dosage
- Antigens, CD - genetics, immunology
- B-Lymphocytes, Regulatory - drug effects, immunology, transplantation
- Colitis - genetics, immunology, pathology
- Female - administration & dosage
- Gastric Mucosa - drug effects, immunology, pathology
- Gene Expression - administration & dosage
- Injections, Intraperitoneal - administration & dosage
- Interleukin-10 - deficiency, genetics, immunology
- Interleukin-33 - administration & dosage
- Interleukins - immunology, pharmacology
- Lymphocyte Activation - administration & dosage
- Mice - administration & dosage
- Mice, Knockout - administration & dosage
- Find related publications in this database (Keywords)
- IL-10
- IL-33
- Regulatory B cell
- Mucosal inflammation
- IBD