Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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SHR Neuro Krebs Kardio Lipid Stoffw Microb
Sattler, S; Reiche, D; Sturtzel, C; Karas, I; Richter, S; Kalb, ML; Gregor, W; Hofer, E.
The human C-type lectin-like receptor CLEC-1 is upregulated by TGF-β and primarily localized in the endoplasmic membrane compartment.
Scand J Immunol. 2012; 75(3): 282-92.
Doi: 10.1111/j.1365-3083.2011.02665.x
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Sattler Susanne
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- Abstract:
- The orphan receptor CLEC-1 is part of a subfamily of C-type lectin-like receptors, which is encoded in the human natural killer gene complex and comprises several pattern recognition receptors important for innate immune functions. As information on human CLEC-1 is still very limited, we aimed to further characterize this receptor. Similar to another subfamily member, LOX-1, expression of CLEC-1 mRNA was detected in myeloid cells as well as in endothelial cells. CLEC-1 protein displayed N-linked glycosylation and formed dimers. However, in contrast to other members of the subfamily, expression levels were upregulated by transforming growth factor (TGF)-β, but not significantly affected by proinflammatory stimuli. It is intriguing that human CLEC-1 could only be detected intracellularly with a staining pattern resembling endoplasmic reticulum proteins. Neither TGF-β nor inflammatory stimuli could promote significant translocation to the cell surface. These findings are in accordance with a primarily intracellular localization and function of human CLEC-1.
- Find related publications in this database (using NLM MeSH Indexing)
- Base Sequence - administration & dosage
- Dendritic Cells - metabolism
- Endoplasmic Reticulum - immunology, metabolism
- Endothelial Cells - metabolism
- Humans - administration & dosage
- Lectins, C-Type - biosynthesis, blood, genetics, immunology
- Leukocytes, Mononuclear - metabolism
- RNA, Messenger - chemistry, genetics
- Real-Time Polymerase Chain Reaction - administration & dosage
- Reverse Transcriptase Polymerase Chain Reaction - administration & dosage
- Sequence Analysis, DNA - administration & dosage
- Transforming Growth Factor beta - immunology, metabolism, pharmacology
- Up-Regulation - administration & dosage