Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Hasham, MG; Baxan, N; Stuckey, DJ; Branca, J; Perkins, B; Dent, O; Duffy, T; Hameed, TS; Stella, SE; Bellahcene, M; Schneider, MD; Harding, SE; Rosenthal, N; Sattler, S.
Systemic autoimmunity induced by the TLR7/8 agonist Resiquimod causes myocarditis and dilated cardiomyopathy in a new mouse model of autoimmune heart disease.
Dis Model Mech. 2017; 10(3): 259-270.
Doi: 10.1242/dmm.027409
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- Führende Autor*innen der Med Uni Graz
- Sattler Susanne
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- Abstract:
- Systemic autoimmune diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) show significant heart involvement and cardiovascular morbidity, which can be due to systemically increased levels of inflammation or direct autoreactivity targeting cardiac tissue. Despite high clinical relevance, cardiac damage secondary to systemic autoimmunity lacks inducible rodent models. Here, we characterise immune-mediated cardiac tissue damage in a new model of SLE induced by topical application of the Toll-like receptor 7/8 (TLR7/8) agonist Resiquimod. We observe a cardiac phenotype reminiscent of autoimmune-mediated dilated cardiomyopathy, and identify auto-antibodies as major contributors to cardiac tissue damage. Resiquimod-induced heart disease is a highly relevant mouse model for mechanistic and therapeutic studies aiming to protect the heart during autoimmunity.
- Find related publications in this database (using NLM MeSH Indexing)
- Adaptive Immunity - drug effects
- Adoptive Transfer - administration & dosage
- Animals - administration & dosage
- Autoantibodies - blood
- Autoimmunity - drug effects
- Cardiomyopathy, Dilated - chemically induced, complications, immunology, physiopathology
- Disease Models, Animal - administration & dosage
- Female - administration & dosage
- Genetic Variation - administration & dosage
- Heart Function Tests - administration & dosage
- Imidazoles - adverse effects
- Immunity, Cellular - drug effects
- Inflammation - pathology
- Lymph Nodes - drug effects, pathology
- Male - administration & dosage
- Mutation - genetics
- Myocarditis - chemically induced, complications, immunology, physiopathology
- Myocardium - pathology
- Spleen - pathology
- Toll-Like Receptor 7 - agonists, metabolism
- Toll-Like Receptor 8 - agonists, metabolism
- Find related publications in this database (Keywords)
- Autoimmunity
- Dilated cardiomyopathy
- Heart disease
- Myocarditis
- Model
- Resiquimod
- Toll-like receptor 7/8