Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Patel, KHK; Jones, TN; Sattler, S; Mason, JC; Ng, FS.
Proarrhythmic electrophysiological and structural remodeling in rheumatoid arthritis.
Am J Physiol Heart Circ Physiol. 2020; 319(5): H1008-H1020.
Doi: 10.1152/ajpheart.00401.2020
Web of Science
PubMed
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- Co-authors Med Uni Graz
- Sattler Susanne
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- Abstract:
- Chronic inflammatory disorders, including rheumatoid arthritis (RA), are associated with a twofold increase in the incidence of sudden cardiac death (SCD) compared with the healthy population. Although this is partly explained by an increased prevalence of coronary artery disease, growing evidence suggests that ischemia alone cannot completely account for the increased risk. The present review explores the mechanisms of cardiac electrophysiological remodeling in response to chronic inflammation in RA. In particular, it focuses on the roles of nonischemic structural remodeling, altered cardiac ionic currents, and autonomic nervous system dysfunction in ventricular arrhythmogenesis and SCD. It also explores whether common genetic elements predispose to both RA and SCD. Finally, it evaluates the potential dual effects of disease-modifying therapy in both diminishing and promoting the risk of ventricular arrhythmias and SCD.
- Find related publications in this database (using NLM MeSH Indexing)
- Action Potentials - administration & dosage
- Animals - administration & dosage
- Arrhythmias, Cardiac - etiology, pathology, physiopathology
- Arthritis, Rheumatoid - complications
- Death, Sudden, Cardiac - etiology
- Humans - administration & dosage
- Ventricular Remodeling - administration & dosage
- Find related publications in this database (Keywords)
- disease-modifying drugs
- electrophysiology
- inflammation
- remodeling
- rheumatoid arthritis
- sudden cardiac death
- ventricular arrhythmia