Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Weiland, T; Sadoghi, B; Pondorfer, P; Kiss, P; Brcic, I; Thurnher, D.
Trichoblastic carcinosarcoma of the neck: Case report and molecular analysis of a seldom, relapsing entity and a review of the literature.
J Dermatol. 2023; 50(5):700-704
Doi: 10.1111/1346-8138.16716
(- Case Report)
Web of Science
PubMed
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FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Brcic Iva
- Sadoghi Birgit
- Weiland Thomas
- Co-Autor*innen der Med Uni Graz
- Kiss Peter
- Pondorfer-Schäfer Prisca
- Thurnher Dietmar
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- Abstract:
- Trichoblastic carcinosarcoma is a seldom biphasic adnexal tumor with malignant epithelial and mesenchymal components. The authors report the first tumor on the neck developed from preexistent trichoblastoma showing aggressive, recurrent behavior. An 82-year-old man presented with a solitary 3-cm exophytic lesion. Histology verified the diagnosis of trichoblastic carcinosarcoma. Four years earlier, a trichoblastic carcinoma arising in a preexisting trichoblastoma was excised at the same location. Despite successful surgical treatments, three local recurrences within 4 years were diagnosed. After the second relapse, the patient agreed on adjuvant radiation. Twelve months later, another relapse was excised in toto. In the last surgical specimen, only the mesenchymal component was found. Copy number variation analysis of the preexisting tumor and two recurrences revealed the same entity and additional chromosomal aberrations in the recurrences. Adnexal carcinosarcomas are seldom, yet presumably underdiagnosed biphasic tumors with aggressive growth potential. They should have adequate preoperative clarification with wide tumor excision, as radiosensitivity seems to be of limited effect.
- Find related publications in this database (using NLM MeSH Indexing)
- Male - administration & dosage
- Humans - administration & dosage
- Aged, 80 and over - administration & dosage
- DNA Copy Number Variations - administration & dosage
- Neoplasm Recurrence, Local - diagnosis, genetics
- Skin Neoplasms - diagnosis, genetics, surgery
- Hair Diseases - pathology
- Carcinosarcoma - diagnosis, genetics, surgery
- Neoplasms, Basal Cell - administration & dosage
- Find related publications in this database (Keywords)
- biphasic tumor
- cutaneous carcinosarcoma
- trichoblastic carcinosarcoma
- trichoblastoma