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SHR Neuro Cancer Cardio Lipid Metab Microb

Rangasamy, L; Geronimo, BD; Ortín, I; Coderch, C; Zapico, JM; Ramos, A; de, Pascual-Teresa, B.
Molecular Imaging Probes Based on Matrix Metalloproteinase Inhibitors (MMPIs).
Molecules. 2019; 24(16): Doi: 10.3390/molecules24162982 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

Co-authors Med Uni Graz: Di Geronimo Quintero Bruno
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Abstract:: Matrix metalloproteinases (MMPs) are a family of zinc- and calcium-dependent endopeptidases which are secreted or anchored in the cell membrane and are capable of degrading the multiple components of the extracellular matrix (ECM). MMPs are frequently overexpressed or highly activated in numerous human diseases. Owing to the important role of MMPs in human diseases, many MMP inhibitors (MMPIs) have been developed as novel therapeutics, and some of them have entered clinical trials. However, so far, only one MMPI (doxycycline) has been approved by the FDA. Therefore, the evaluation of the activity of a specific subset of MMPs in human diseases using clinically relevant imaging techniques would be a powerful tool for the early diagnosis and assessment of the efficacy of therapy. In recent years, numerous MMPIs labeled imaging agents have emerged. This article begins by providing an overview of the MMP subfamily and its structure and function. The latest advances in the design of subtype selective MMPIs and their biological evaluation are then summarized. Subsequently, the potential use of MMPI-labeled diagnostic agents in clinical imaging techniques are discussed, including positron emission tomography (PET), single-photon emission computed tomography (SPECT) and optical imaging (OI). Finally, this article concludes with future perspectives and clinical utility.
Find related publications in this database (using NLM MeSH Indexing): Animals - administration & dosage; Atherosclerosis - diagnostic imaging, metabolism, pathology; Cardiovascular Diseases - diagnostic imaging, metabolism, pathology; Catalytic Domain - genetics; Disease Models, Animal - administration & dosage; Encephalomyelitis, Autoimmune, Experimental - diagnostic imaging, metabolism, pathology; Extracellular Matrix - metabolism, pathology; Humans - administration & dosage; Lung Diseases - diagnostic imaging, metabolism, pathology; Matrix Metalloproteinase Inhibitors - chemical synthesis, pharmacokinetics; Matrix Metalloproteinases - chemistry, genetics, metabolism; Molecular Imaging - methods; Molecular Probes - chemical synthesis, pharmacokinetics; Multiple Sclerosis - diagnostic imaging, metabolism, pathology; Neoplasms - diagnostic imaging, metabolism, pathology; Osteoarthritis - diagnostic imaging, metabolism, pathology; Positron-Emission Tomography - methods; Tomography, Emission-Computed, Single-Photon - methods
Find related publications in this database (Keywords): Matrix metalloproteinases (MMPs); positron emission tomography (PET); single-photon emission computed tomography (SPECT) and optical imaging (OI)