Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Werkl, P; Rademacher, J; Pleyer, U.
[HLA-B27 positive anterior uveitis : Clinical aspects, diagnostics, interdisciplinary management and treatment].
Ophthalmologie. 2023; 120(1): 108-122. Doi: 10.1007/s00347-022-01793-2
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Führende Autor*innen der Med Uni Graz: Werkl Peter Johannes
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Abstract:: Acute anterior uveitis (AAU) associated with human leukocyte antigen (HLA) B27 is the most common form of noninfectious intraocular inflammation and is considered to be a separate clinical entity. Young adults between the ages of 20 and 40 years are predominantly affected. The HLA-B27 positive AAU typically presents as a unilateral, fulminant disruption of the blood-aqueous humor barrier, which is accompanied by pronounced cellular infiltration and fibrinous exudation. Other characteristics are reduced intraocular pressure and a high tendency to relapse, which can also involve the partner eye. Patients with HLA-B27 positive AAU share a high risk for other genetically associated diseases, especially spondylarthritis, chronic inflammatory bowel diseases and psoriasis. As up to 40% of those affected have a systemic disease that has not yet been diagnosed, the ophthalmologist is of major importance for early detection.
Find related publications in this database (using NLM MeSH Indexing): Young Adult - administration & dosage; Humans - administration & dosage; Adult - administration & dosage; HLA-B27 Antigen - genetics; Uveitis, Anterior - diagnosis; Uveitis - administration & dosage; Inflammation - administration & dosage; Spondylarthritis - administration & dosage; Acute Disease - administration & dosage
Find related publications in this database (Keywords): Acute anterior uveitis; Clinical manifestations; Psoriasis; Spondylarthritis; Systemic disease