Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Stattin, M; Ahmed, D; Haas, AM; Graf, A; Zehetner, C; Mihalics, S; Krepler, K; Ansari-Shahrezaei, S.
OPTICAL COHERENCE TOMOGRAPHY AND OCT ANGIOGRAPHY CHARACTERISTICS OF INDOCYANINE GREEN ANGIOGRAPHIC PLAQUES IN NONEXUDATIVE AGE-RELATED MACULAR DEGENERATION
RETINA-J RET VIT DIS. 2023; 43(1): 16-24. Doi: 10.1097/IAE.0000000000003639
Web of Science PubMed FullText FullText_MUG

Führende Autor*innen der Med Uni Graz: Ansari Shahrezaei Siamak
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Abstract:: Purpose:To describe characteristics of indocyanine green (ICG) angiographic plaques in the nonexudative fellow eye of White patients with unilateral treatment-naive exudative neovascular age-related macular degeneration through optical coherence tomography (OCT) and OCT angiography (OCTA).Methods:In this retrospective cross-sectional study, nonexudative eyes with ICG angiographic plaques were analyzed by OCT B-scans for the sensitivity of a double-layer sign, a pigment epithelium detachment, outer retinal atrophy, hyperreflective dots, and subretinal hyperreflective material (SRHM). The ICG angiographic plaque was matched with a macular neovascularization in OCTA en face scans and color-coded B scans.Results:In total, 35 ICG angiographic plaques in 33 of 291 (11%) nonexudative eyes were diagnosed. OCT revealed 27 double-layer sign (78%), eight pigment epithelium detachment (23%), 8 outer retinal atrophy (23%), eight hyperreflective dots (23%), and one subretinal hyperreflective material (3%). OCTA confirmed a macular neovascularization in 28 plaques (80%): 7 (20%) in en face scans, 3 (9%) in color-coded B scans, and 18 (51%) in both. The area size in OCTA was significantly smaller than that of ICG angiography (P = 0.002).Conclusion:The diagnosis of an ICG angiographic plaque in nonexudative fellow eyes of Whites with unilateral treatment-naive exudative neovascular age-related macular degeneration was highly suggestive of a typical macular neovascularization type 1 as characterized by OCT and OCTA.
Find related publications in this database (Keywords): age-related macular degeneration; indocyanine green angiography; macular neovascularization; nonexudative; plaque; optical coherence tomography angiography; swept source