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Salzer, B; Stavljenic, A; Jürgens, G; Dumic, M; Radica, A.
Polymorphism of apolipoprotein E, lipoprotein(a), and other lipoproteins in children with type I diabetes.
Clin Chem. 1993; 39(7):1427-1432 Doi: 10.1093/clinchem/39.7.1427 [OPEN ACCESS]
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Co-authors Med Uni Graz: Jürgens Günther
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Abstract:: We assessed the effect of particular apolipoprotein (apo) E phenotypes, lipoprotein(a) [Lp(a)], and other lipoproteins on the development of dyslipoproteinemia in 450 patients with type I diabetes, ages 13-14 years. The control group consisted of 450 healthy school children of both sexes, ages 13-14 years. Both groups were found to be normolipidemic, but the concentration of Lp(a) was significantly (P < 0.05) higher in the diabetic children than in the control group. Apo E 3/2 and apo E 4/4 phenotypes were more frequent in the group of diabetics. Diabetics with the apo E 3/3 phenotype had higher concentrations of very-low-density lipoprotein (VLDL) and Lp(a), and lower concentrations of low-density lipoprotein (LDL) than the apo E 3/3 nondiabetics. For apo E 3/2 phenotypes, total cholesterol, LDL cholesterol, LDL, apo A-I, and Lp(a) concentrations were higher in the diabetic children than in the control group; for apo E 4/3 phenotypes, this was true for triglycerides and VLDL cholesterol. The distribution of Lp(a) lipoprotein concentrations between 0.01 and > 0.5 g/L indicated a more frequent occurrence of higher Lp(a) values in diabetic children than in the control group. Results of this study indicate that an increased concentration of Lp(a) lipoprotein and apo E 3/2 and apo E 4/3 phenotypes contribute to the expression of dyslipoproteinemia in type I diabetes in childhood.
Find related publications in this database (using NLM MeSH Indexing): Adolescent -; Apolipoproteins E - blood; Cholesterol - blood; Diabetes Mellitus, Type 1 - blood; Female - blood; Humans - blood; Isoelectric Focusing - blood; Lipoprotein(a) - blood; Lipoproteins - blood; Lipoproteins, LDL - blood; Lipoproteins, VLDL - blood; Male - blood; Phenotype - blood; Polymorphism, Genetic - blood; Reference Values - blood; Triglycerides - blood