Hasenleithner, SO; Speicher, MR.
How to detect cancer early using cell-free DNA.
Cancer Cell. 2022; 40(12): 1464-1466.
Doi: 10.1016/j.ccell.2022.11.009
Web of SciencePubMedFullTextFullText_MUG
Cell-free circulating DNA (cfDNA) analyses may enable multi-cancer early detection (MCED), but the most suitable method is unknown. In this issue of Cancer Cell, Jamshidi et al. compare ten machine-learning classifiers using various cfDNA features and conclude that cfDNA methylation patterns are most promising for MCED testing.
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