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Fleischhacker, WW; Hofer, A; Jagsch, C; Pirker, W; Psota, G; Rittmannsberger, H; Seppi, K.
[Antipsychotic-induced tardive syndromes].
Neuropsychiatr. 2016; 30(3): 123-130. Doi: 10.1007/s40211-016-0189-7
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Co-authors Med Uni Graz: Jagsch Christian
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Abstract:: Tardive dyskinesia (TD) remains a relevant clinical problem despite the increasing use of new-generation antipsychotics. Antipsychotic-induced tardive syndromes are difficult to treat and have a low tendency of remission. Therefore, prophylaxis is of utmost importance, with the responsible use of antipsychotics as a prime desideratum. With respect to managing tardive dyskinesia, discontinuing the antipsychotic, if possible, albeit not backed up by unequivocal evidence, is still the main recommendation. If this is not possible, the switch to an antipsychotic with a lower TD risk is the next-preferred option. Other symptomatic treatments have been explored, but clinical trials have provided inhomogeneous results and only very few compounds are approved for the treatment of tardive dyskinesia. This manuscript summarizes the current evidence with respect to the phenomenology, course, prevention and treatment of tardive syndromes.
Find related publications in this database (using NLM MeSH Indexing): Antipsychotic Agents - adverse effects, therapeutic use; Clinical Trials as Topic - administration & dosage; Drug Substitution - administration & dosage; Evidence-Based Medicine - administration & dosage; Follow-Up Studies - administration & dosage; Humans - administration & dosage; Risk Factors - administration & dosage; Tardive Dyskinesia - diagnosis, drug therapy, etiology, prevention & control
Find related publications in this database (Keywords): Tardive syndrome; Tardive dyskinesia; Antipsychotic; Prophylaxis; Treatment