Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Sucher, E; Sucher, R; Gradistanac, T; Brandacher, G; Schneeberger, S; Berg, T.
Autoimmune Hepatitis-Immunologically Triggered Liver Pathogenesis-Diagnostic and Therapeutic Strategies.
J Immunol Res. 2019; 2019:9437043
Doi: 10.1155/2019/9437043
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- Leading authors Med Uni Graz
- Sucher Robert
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- Abstract:
- Autoimmune hepatitis (AIH) is a severe liver disease that arises in genetically predisposed male and female individuals worldwide. Diagnosis of AIH is made clinically applying diagnostic scores; however, the heterotopic disease phenotype often makes a rapid determination of disease challenging. AIH responds favorably to steroids and pharmacologic immunosuppression, and liver transplantation is only necessary in cases with acute liver failure or end-stage liver cirrhosis. Recurrence or development of de novo AIH after transplantation is possible, and treatment is similar to standard AIH therapy. Current experimental investigations of T cell-mediated autoimmune pathways and analysis of changes within the intestinal microbiome might advance our knowledge on the pathogenesis of AIH and trigger a spark of hope for novel therapeutic strategies.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals - administration & dosage
- Autoimmunity - administration & dosage
- Biomarkers - administration & dosage
- Combined Modality Therapy - administration & dosage
- Disease Susceptibility - immunology
- Hepatitis, Autoimmune - diagnosis, epidemiology, etiology, therapy
- Humans - administration & dosage
- Risk Factors - administration & dosage
- Severity of Illness Index - administration & dosage
- Treatment Outcome - administration & dosage