Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Ollinger, R; Kogler, P; Biebl, M; Sieb, M; Sucher, R; Bösmüller, C; Troppmair, J; Mark, W; Weiss, H; Margreiter, R.
Protein levels of heme oxygenase-1 during reperfusion in human kidney transplants with delayed graft function.
Clin Transplant. 2008; 22(4):418-23
Doi: 10.1111/j.1399-0012.2008.00800.x
Web of Science
PubMed
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- Co-authors Med Uni Graz
- Sucher Robert
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- Abstract:
- INTRODUCTION: Delayed graft function (DGF) as a consequence of ischemia reperfusion injury (IRI) is associated with a decrease in long-term allograft survival. Heme oxygenase-1 (HO-1) is a stress responsive gene that is highly expressed in multiple pathological processes. The aim of our study was to analyze whether HO-1 protein levels in human kidney transplants during IRI correlate with the incidence of DGF. METHODS: Kidney biopsies were obtained from 27 kidney allografts at two time points: at the end of cold storage and shortly after reperfusion. Samples were analyzed for HO-1 protein levels by Western blot. RESULTS: Heme oxygenase-1 protein levels were significantly higher in post-reperfusion biopsies (39.4 vs. 13.7 arbitrary units, p = 0.001). In pre-reperfusion biopsies no association was observed between HO-1 protein levels and DGF. In post-reperfusion biopsies, higher levels of HO-1 protein were measured in kidneys with DGF (53.7 vs. 36.2 arbitrary units, p = 0.064). DGF kidneys showed a significantly higher increase from pre- to post-reperfusion in HO-1 protein (42.0 vs. 18.7 arbitrary units, p = 0.025). CONCLUSION: Heme oxygenase-1 protein levels shortly after allograft reperfusion are closely related with initial graft function. Assessment thereof may be considered a valuable tool to predict DGF.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent - administration & dosage
- Adult - administration & dosage
- Aged - administration & dosage
- Blotting, Western - administration & dosage
- Child - administration & dosage
- Child, Preschool - administration & dosage
- Delayed Graft Function - enzymology
- Female - administration & dosage
- Graft Survival - physiology
- Heme Oxygenase-1 - metabolism
- Humans - administration & dosage
- Ischemic Preconditioning - administration & dosage
- Kidney Transplantation - administration & dosage
- Male - administration & dosage
- Middle Aged - administration & dosage
- Reperfusion - administration & dosage
- Reperfusion Injury - enzymology
- Tissue Donors - administration & dosage
- Transplantation, Homologous - administration & dosage
- Young Adult - administration & dosage
- Find related publications in this database (Keywords)
- heme oxygenase-1
- delayed graft function
- kidney transplantation
- ischemia reperfusion injury