Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Kabasser, S; Radauer, C; Eber, E; Haber, ME; Hieden, K; Zieglmayer, P; Kost, LE; Sindher, SB; Chinthrajah, S; Geiselhart, S; Hoffmann-Sommergruber, K; Nadeau, KC; Breiteneder, H; Bublin, M.
Cosensitization to the 3 Nonhomologous Major Cashew Allergens Ana o 1, Ana o 2, and Ana o 3 Is Caused by IgE Cross-reactivity.
J Investig Allergol Clin Immunol. 2024; 34(1):38-48
Doi: 10.18176/jiaci.0867
Web of Science
PubMed
FullText
FullText_MUG
- Co-authors Med Uni Graz
- Eber Ernst
- Haber Elisabeth Maria
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- BACKGROUND: Cashew nuts often cause strong allergic reactions, which are even more severe than those of peanuts. Ana o 1 (vicilin), Ana o 2 (legumin), and Ana o 3 (2S albumin) are major cashew allergens. Cosensitization to all 3 nonhomologous cashew nut allergens has been observed. We hypothesize that this might be due to IgE cross-reactivity. METHODS: IgE cross-inhibitions were performed with Ana o 1-3 using serum samples from cashew nut-allergic patients. The related hazelnut allergens Cor a 11, 9, and 14 were used as controls. For comparison, IgE cross-reactivity between the hazelnut allergens was investigated using serum samples from hazelnut-allergic patients. RESULTS: The median percentages of cross-inhibition between Ana o 1, 2, and 3 were 84%-99%. In comparison, the median cross- inhibition values between hazelnut allergens were 33%-62%. The IC50 values revealed the highest IgE affinity to be to Ana o 3 and Cor a 14. Hazelnut legumin Cor a 9 inhibited IgE binding to Ana o 1, 2, and 3, with median percentages of 75%, 56%, and 48%, respectively. No cross-reactivity was observed between allergenic vicilins or between 2S albumins from cashew and hazelnut. Potentially cross-reactive peptides of Ana o 3 identified in silico overlapped with previously reported IgE epitopes of all 3 allergens. CONCLUSION: IgE with high affinity to Ana o 3 that cross-reacts with the other 2 major nonhomologous cashew nut allergens might be responsible for the high allergenic potency of cashew nut. These cross-reactive IgE types comprise the major fraction of specific IgE in cashew-allergic patients and might be responsible for cross-reactivity between unrelated tree nuts.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Allergens - metabolism
- Nut Hypersensitivity - diagnosis
- Anacardium - metabolism
- Antigens, Plant - administration & dosage
- Immunoglobulin E - administration & dosage
- Legumins - administration & dosage
- Find related publications in this database (Keywords)
- Cashew nut allergy
- IgE cross-reactivity
- Food allergens
- Food allergy
- Hazelnut allergy
- Hazelnut allergens
- Tree nut allergy