Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Fakheran, O; Dehghannejad, M; Khademi, A.
Saliva as a diagnostic specimen for detection of SARS-CoV-2 in suspected patients: a scoping review.
Infect Dis Poverty. 2020; 9(1): 100
Doi: 10.1186/s40249-020-00728-w
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- Führende Autor*innen der Med Uni Graz
- Fakheran Esfahani Omid
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- Abstract:
- BACKGROUND: From the begging months of 2020 a severe acute respiratory syndrome coronavirus (SARS-CoV-2, also called 2019-nCoV) caused a devastating global outbreak. At present, the diagnosis of coronavirus disease 2019 (COVID-19) is made through a nasopharyngeal swab based on reverse transcription polymerase chain reaction (RT-PCR) technique. However, some recent studies suggested the possible role of oral fluids and saliva in the detection of SARS-CoV-2. The purpose of this scoping review is evaluating the available evidence regarding the efficacy of saliva as a diagnostic specimen in COVID-19 patients. METHODS: A systematic literature review of six databases (PubMed, Scopus, The Cochrane Central Register of Controlled Trials [CENTRAL], Science Direct, Web of Science and Google scholar) was carried out without any restrictions on date of publication to identify the reliability of saliva as a diagnostic specimen for detection of SARS-CoV-2 in suspected patients. RESULTS: Nine eligible articles were included in this review based on our described method. All the included studies are based on clinical surveys among patients with confirmed SARS-CoV-2 infection. Most of studies included in this review, reported that there is no statistically significant difference between nasopharyngeal or sputum specimens and saliva samples regarding viral load. CONCLUSIONS: Despite limitations of this study, the findings of this review suggest that the use of self-collected saliva as a non-invasive specimen has proper accuracy and reliability regarding detection of SARS-CoV-2 based on RT-PCR technique.
- Find related publications in this database (using NLM MeSH Indexing)
- Betacoronavirus - isolation & purification
- COVID-19 - administration & dosage
- Coronavirus Infections - diagnosis
- Humans - administration & dosage
- Pandemics - administration & dosage
- Pneumonia, Viral - diagnosis
- Reproducibility of Results - administration & dosage
- SARS-CoV-2 - administration & dosage
- Saliva - virology
- Viral Load - administration & dosage
- Find related publications in this database (Keywords)
- COVID-19
- SARS-CoV-2
- 2019-nCoV
- Saliva
- PCR
- Review