Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Mahdavi, A; Bagherniya, M; Fakheran, O; Reiner, Ž; Xu, S; Sahebkar, A.
Medicinal plants and bioactive natural compounds as inhibitors of HMG-CoA reductase: A literature review.
Biofactors. 2020; 46(6): 906-926.
Doi: 10.1002/biof.1684
Web of Science
PubMed
FullText
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- Co-Autor*innen der Med Uni Graz
- Fakheran Esfahani Omid
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- Abstract:
- Cardiovascular diseases (CVDs) are one of the most important causes for mortality worldwide. Elevated levels of total cholesterol, and particularly LDL-cholesterol (LDL-C) are the main risk factor for acute myocardial infarction (AMI) and ischemic heart disease. The risk of CVDs could be reduced by decreasing the elevated cholesterol levels. β-hydroxy β-methylglutaryl-CoA reductase (HMGCoAR) is the primary and rate-limiting enzyme in the cholesterol biosynthesis pathway. Recently, the crucial role of nutraceuticals in maintaining normal physiological function was established. Nutraceuticals play an important role in preventing several non-communicable diseases such as obesity, CVDs, cancer, diabetes, and reducing hyperlipidemia. Although the effect of nutraceuticals and herbal medicine on CVDs and dyslipidemia was previously investigated thoroughly, the effect of these natural products on HMGCoAR as one of the important enzymes involved in CVDs etiopathogenesis has not yet been investigated. Therefore, the major aim of this paper was to review the effects of nutraceuticals and medicinal plants on HMGCoAR. Results indicate that different types of natural foods, isolated nutrients, herbal products, and dietary supplements as nutraceuticals decrease the expression and activity of HMGCoAR. This review shows that medicinal plants and nutraceuticals could be used to decrease HMGCoAR activity as accessible and convenient and economical natural compounds to prevent dyslipidemia and CVDs.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Hydroxymethylglutaryl CoA Reductases - drug effects
- Hypercholesterolemia - prevention & control
- Phytochemicals - pharmacology
- Plants, Medicinal - administration & dosage
- Find related publications in this database (Keywords)
- cardiovascular diseases
- cholesterol
- HMG-CoA reductase
- nutraceuticals
- herbal medicine