Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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SHR Neuro Krebs Kardio Lipid Stoffw Microb
Fattah, M; Boughton, CK; Ware, J; Allen, JM; Hartnell, S; Willinska, ME; Thankamony, A; de, Beaufort, C; Campbell, FM; Fröhlich-Reiterer, E; Hofer, SE; Kapellen, TM; Rami-Merhar, B; Ghatak, A; Randell, TL; Besser, REJ; Elleri, D; Trevelyan, N; Denvir, Md, L; Davis, N; Bally, L; Thabit, H; Leelarathna, L; Evans, ML; Mader, JK; Hovorka, R.
Evaluating the Impact of Applying Personal Glucose Targets in a Closed-Loop System for People With Type 1 Diabetes.
J Diabetes Sci Technol. 2024; 18(3):695-700
Doi: 10.1177/19322968221145184
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- Co-Autor*innen der Med Uni Graz
- Fröhlich-Reiterer Elke
- Mader Julia
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- Abstract:
- BACKGROUND: CamAPS FX is a hybrid closed-loop smartphone app used to manage type one diabetes. The closed-loop algorithm has a default target glucose of 5.8 mmol/L (104.5 mg/dL), but users can select personal glucose targets (adjustable between 4.4 mmol/L and 11.0 mmol/L [79 mg/dL and 198 mg/dL, respectively]). METHOD: In this post-hoc analysis, we evaluated the impact of personal glucose targets on glycemic control using data from participants in five randomized controlled trials. RESULTS: Personal glucose targets were widely used, with 20.3% of all days in the data set having a target outside the default target bin (5.5-6.0 mmol/L [99-108 mg/dL]). Personal glucose targets >6.5 mmol/L (117 mg/dL) were associated with significantly less time in target range (3.9-10.0 mmol/L [70-180 mg/dL]; 6.5-7.0 mmol/L [117-126 mg/dL]: mean difference = -3.2 percentage points [95% CI: -5.3 to -1.2; P < .001]; 7.0-7.5 mmol/L [126-135 mg/dL]: -10.8 percentage points [95% CI: -14.1 to -7.6; P < .001]). Personal targets >6.5 mmol/L (117 mg/dL) were associated with significantly lower time (<3.9 mmol/L [<70 mg/dL]; 6.5-7.0 mmol/L [117-126 mg/dL]: -1.85 percentage points [95% CI: -2.37 to -1.34; P < .001]; 7.0-7.5 mmol/L [126-135 mg/dL]: -2.68 percentage points [95% CI: -3.49 to -1.86; P < .001]). CONCLUSIONS: Discrete study populations showed differences in glucose control when applying similar personal targets.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Diabetes Mellitus, Type 1 - blood, drug therapy
- Blood Glucose - analysis, drug effects
- Blood Glucose Self-Monitoring - administration & dosage
- Mobile Applications - administration & dosage
- Insulin Infusion Systems - administration & dosage
- Glycemic Control - administration & dosage
- Adult - administration & dosage
- Hypoglycemic Agents - administration & dosage
- Insulin - administration & dosage
- Female - administration & dosage
- Male - administration & dosage
- Algorithms - administration & dosage
- Smartphone - administration & dosage
- Middle Aged - administration & dosage
- Find related publications in this database (Keywords)
- algorithm
- glucose control
- hybrid closed-loop
- personal glucose target
- type 1 diabetes