Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Reider, S; Binder, L; Fürst, S; Hatzl, S; Blesl, A.
Hematopoietic Stem Cell Transplantation in Refractory Crohn's Disease: Should It Be Considered?
Cells. 2022; 11(21):
Doi: 10.3390/cells11213463
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Blesl Andreas
- Co-authors Med Uni Graz
- Binder Lukas
- Fürst Stefan
- Hatzl Stefan
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- Abstract:
- Hematopoietic stem cell transplantation (HSCT) is widely used in benign and malignant hematological diseases. During the last decade, HSCT, mainly autologous, also gained increasing attention in the treatment of refractory autoimmune diseases. Crohn's disease (CD) is an inflammatory bowel disease leading to transmural inflammation potentially affecting all parts of the luminal gastrointestinal tract. Despite improving therapeutic options, including various biologics, some patients are refractory to all lines of available conservative therapy, leading to increased morbidity and reduced quality of life. Apart from surgery, HSCT might be a reasonable treatment alternative for refractory CD patients. This review aims to describe the current role of HSCT in CD and discusses the procedure, the correct patient selection, the clinical efficacy from initial remission to following relapse rates, and complications of this treatment.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Crohn Disease - therapy
- Quality of Life - administration & dosage
- Hematopoietic Stem Cell Transplantation - methods
- Transplantation, Autologous - administration & dosage
- Inflammatory Bowel Diseases - etiology
- Chronic Disease - administration & dosage
- Find related publications in this database (Keywords)
- Crohn's disease
- inflammatory bowel disease
- hematopoietic stem cell transplantation
- chemotherapy