Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Braunwarth, E; Ratti, F; Aldrighetti, L; Al-Saffar, HA; D, Souza, MA; Sturesson, C; Linke, R; Schnitzbauer, A; Bodingbauer, M; Kaczirek, K; Vagg, D; Toogood, G; Ferraro, D; Fusai, GK; Diaz-Nieto, R; Malik, H; Hoogwater, FJH; Wagner, D; Kornprat, P; Fischer, I; Függer, R; Göbel, G; Öfner, D; Stättner, S.
Incidence and risk factors for anastomotic bile leakage in hepatic resection with bilioenteric reconstruction - A international multicenter study.
HPB (Oxford). 2023; 25(1):54-62
Doi: 10.1016/j.hpb.2022.08.009
Web of Science
PubMed
FullText
FullText_MUG
- Co-authors Med Uni Graz
- Kornprat Peter
- Wagner Doris
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- Abstract:
- BACKGROUND: Anastomotic leak (AL) after bilioenteric reconstruction (BR) is a feared complication after bile duct resection, especially in combination with liver resection. Literature on surgical outcome is sparse. This study aimed to determine the incidence and risk factors for AL after combined liver and bile duct resection with a focus on operative or endoscopic reinterventions. METHODS: Data from consecutive patients who underwent liver resection and BR between 2004 and 2018 in 11 academic institutions in Europe were collected from prospectively maintained databases. RESULTS: Within 921 patients, AL rate was 5.4% with a 30d mortality of 9.6%. Pringle maneuver (p<0.001),postoperative external biliary (p=0.007) and abdominal drainage (p<0.001) were risk factors for clinically relevant AL. Preoperative biliary drainage (p<0.001) was not associated with a higher rate of AL. AL was more frequent in stented patients (76.5%) compared to PTCD (17.6%) or PTCD+stent (5.9%,p=0.017). AL correlated with increased incidence of postoperative liver failure (p=0.036), cholangitis, hemorrhage and sepsis (all p<0.001). CONCLUSION: This multicenter data provides the largest series to date of LR with BR and could help in the management of these patients which are often challenging and hampering the patients' postoperative course negatively.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Anastomotic Leak - epidemiology, etiology
- Bile - administration & dosage
- Incidence - administration & dosage
- Liver - surgery
- Biliary Tract Diseases - etiology
- Postoperative Complications - epidemiology, therapy, etiology
- Hepatectomy - adverse effects
- Drainage - adverse effects
- Risk Factors - administration & dosage
- Retrospective Studies - administration & dosage