Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Gawish, A; Abdulayev, N; El-Arayed, S; Röllich, B; Ochel, HJ; Brunner, TB.
A single-center experience with linear accelerator-based stereotactic radiotherapy for meningiomas: hypofractionation and radiosurgery.
J Cancer Res Clin Oncol. 2023; 149(1):103-109
Doi: 10.1007/s00432-022-04450-y
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- Co-Autor*innen der Med Uni Graz
- Brunner Thomas Baptist
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- Abstract:
- PURPOSE: Meningioma is a common type of benign tumor that can be managed in several ways, ranging from close observation, surgical resection, and various types of radiation. We present here results from a 10 year experience treating meningiomas with a hypofractionated approach. MATERIALS AND METHODS: To define the rate of tumor control and factors associated with the relief of symptoms and radiation-related complications after radiosurgery and hypofractionated radiosurgery for patients with imaging-defined intracranial meningiomas. We reviewed the charts of 48 patients treated with stereotactic radiosurgery (SRS) or hypofractionated stereotactic radiotherapy (SRT) from 2002 to 2018. A total of 37 (82%) patients had WHO Grade 1 disease, and 11 (22%) had Grade 2. Outcomes that were analyzed included local control rates and the rate and grade of any reported toxicity. RESULTS: Only 36 patients with 38 lesions, who underwent the follow-up regime, were enrolled in the retrospective analysis. The follow-up mean was 40 months (12-120 months). 25/34 patients had surgery before the radiotherapy. Sixteen underwent SRS with a median dose of 13, 5, and 20 received hypofractionated SBRT with a median dose of 26.9 (22-45 Gy) in median six fractions (5-13 fractions). Local control at 2 and 5 years for all patients was 90 and 70%, respectively. No patient suffered from toxicity > 2 CTC. 21/36 patients showed stable disease, while 8/36 patients showed partial Remission. 7/36 developed recurrent meningioma (five in-field), only one patient with grade 1 meningioma, in a median of 22 months (13-48 months). CONCLUSION: SFRT was superior to SRS for local control in our analysis of Grade I meningiomas. This might be due to a tendency for higher EQD2 in the PTV with SFRT compared to SRS, which was reduced to avoid brain necrosis in large PTVs. Therefore, SFRT appears preferable for typical meningioma PTVs.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Meningioma - surgery
- Radiosurgery - adverse effects, methods
- Meningeal Neoplasms - radiotherapy, surgery
- Retrospective Studies - administration & dosage
- Radiation Dose Hypofractionation - administration & dosage
- Follow-Up Studies - administration & dosage
- Neoplasm Recurrence, Local - surgery
- Particle Accelerators - administration & dosage
- Treatment Outcome - administration & dosage
- Find related publications in this database (Keywords)
- SRS
- Radiosurgery
- Hypofractionated radiotherapy
- Meningioma