Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Baranyi, A; Enko, D; Meinitzer, A; Von Lewinski, D; Rothenhäusler, HB; Harpf, L; Traninger, H; Obermayer-Pietsch, B; Harb, BM; Schweinzer, M; Platzer, M; Zelzer, S.
Myeloperoxidase as a Potential Biomarker of Acute-Myocardial-Infarction-Induced Depression and Suppression of the Innate Immune System.
Antioxidants (Basel). 2022; 11(11):
Doi: 10.3390/antiox11112083
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- Führende Autor*innen der Med Uni Graz
- Baranyi Andreas
- von Lewinski Dirk
- Co-Autor*innen der Med Uni Graz
- Enko Dietmar
- Meinitzer Andreas
- Obermayer-Pietsch Barbara
- Rothenhäusler Hans-Bernd
- Schweinzer Melanie Sonja
- Zelzer Sieglinde
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- Abstract:
- While myeloperoxidase (MPO) serves as an indicator of both neutrophil and innate-immune-system function, the potential suppression of the innate immune system in patients with acute myocardial infarction (AMI)-induced depression might be evidenced by a decrease in MPO serum levels. The aim of this prospective study was to (1) determine whether serum concentrations of MPO vary immediately and 6 months after AMI and (2) to investigate whether MPO concentrations at the time of the AMI are significant predictors of AMI-induced depression and the depression-associated suppression of the innate immune system. A total of 109 AMI patients were assessed with the Hamilton Depression Scale (HAMD-17) immediately after admission to the hospital and 6 months later. The MPO status was assessed with serum samples, which were also collected immediately and 6 months after AMI. The depressive patients showed significantly lower MPO blood levels immediately and 6 months after the AMI compared to the patients without depression (ANCOVA: MPO (depression) F = 4.764, df = 1, p = 0.031). The baseline MPO was observed as a significant predictor (p = 0.027) of AMI-induced depression 6 months after AMI. MPO is a potential biomarker for AMI-induced depression, indicating a depression-associated suppression of the innate immune system.
- Find related publications in this database (Keywords)
- myeloperoxidase
- depression
- innate immune system
- acute myocardial infarction