Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
de, Beaufort, C; Schierloh, U; Thankamony, A; Ware, J; Wilinska, ME; Fröhlich-Reiterer, E; Kapellen, TM; Rami-Merhar, B; Hofer, SE; Campbell, FM; Yong, J; Bocchino, LE; Sibayan, J; Lawton, J; Roze, S; Fritsch, M; Thiele, A; Allen, JM; Boughton, C; Mader, JK; Kollman, C; Hovorka, R; Pit-Ten Cate, IM; KidsAP Consortium.
Cambridge Hybrid Closed-Loop System in Very Young Children With Type 1 Diabetes Reduces Caregivers' Fear of Hypoglycemia and Improves Their Well-Being.
Diabetes Care. 2022; 45(12):3050-3
Doi: 10.2337/dc22-0693
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- Co-Autor*innen der Med Uni Graz
- Fritsch Maria
- Fröhlich-Reiterer Elke
- Mader Julia
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- Abstract:
- OBJECTIVE: To evaluate the impact of CamAPS FX hybrid closed-loop (HCL) automated insulin delivery in very young children with type 1 diabetes (T1D) on caregivers' well-being, fear of hypoglycemia, and sleepiness. RESEARCH DESIGN AND METHODS: We conducted a multinational, open-label, randomized crossover study. Children (age 1-7 years) with T1D received treatment for two 4-month periods in random order, comparing HCL with sensor augmented pump (control). At baseline and after each treatment period, caregivers were invited to complete World Health Organization-Five Well-Being Index, Hypoglycemia Fear Survey, and Epworth Sleepiness Scale questionnaires. RESULTS: Caregivers of 74 children (mean ± SD age 5 ± 2 years and baseline HbA1c 7.3 ± 0.7%; 42% female) participated. Results revealed significantly lower scores for hypoglycemia fear (P < 0.001) and higher scores for well-being (P < 0.001) after HCL treatment. A trend toward a reduction in sleepiness score was observed (P = 0.09). CONCLUSIONS: Our results suggest better well-being and less hypoglycemia fear in caregivers of very young children with T1D on CamAPS FX HCL.