Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Wölfel, EM; Schmidt, FN; Vom, Scheidt, A; Siebels, AK; Wulff, B; Mushumba, H; Ondruschka, B; Püschel, K; Scheijen, J; Schalkwijk, CG; Vettorazzi, E; Jähn-Rickert, K; Gludovatz, B; Schaible, E; Amling, M; Rauner, M; Hofbauer, LC; Zimmermann, EA; Busse, B.
Dimorphic Mechanisms of Fragility in Diabetes Mellitus: the Role of Reduced Collagen Fibril Deformation.
J Bone Miner Res. 2022; 37(11):2259-2276
Doi: 10.1002/jbmr.4706
Web of Science
PubMed
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- vom Scheidt Annika
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- Abstract:
- Diabetes mellitus (DM) is an emerging metabolic disease, and the management of diabetic bone disease poses a serious challenge worldwide. Understanding the underlying mechanisms leading to high fracture risk in DM is hence of particular interest and urgently needed to allow for diagnosis and treatment optimization. In a case-control postmortem study, the whole 12th thoracic vertebra and cortical bone from the mid-diaphysis of the femur from male individuals with type 1 diabetes mellitus (T1DM) (n = 6; 61.3 ± 14.6 years), type 2 diabetes mellitus (T2DM) (n = 11; 74.3 ± 7.9 years), and nondiabetic controls (n = 18; 69.3 ± 11.5) were analyzed with clinical and ex situ imaging techniques to explore various bone quality indices. Cortical collagen fibril deformation was measured in a synchrotron setup to assess changes at the nanoscale during tensile testing until failure. In addition, matrix composition was analyzed including determination of cross-linking and non-crosslinking advanced glycation end-products like pentosidine and carboxymethyl-lysine. In T1DM, lower fibril deformation was accompanied by lower mineralization and more mature crystalline apatite. In T2DM, lower fibril deformation concurred with a lower elastic modulus and tendency to higher accumulation of non-crosslinking advanced glycation end-products. The observed lower collagen fibril deformation in diabetic bone may be linked to altered patterns mineral characteristics in T1DM and higher advanced glycation end-product accumulation in T2DM. © 2022 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).
- Find related publications in this database (using NLM MeSH Indexing)
- Male - administration & dosage
- Humans - administration & dosage
- Diabetes Mellitus, Type 1 - complications, diagnostic imaging
- Diabetes Mellitus, Type 2 - metabolism
- Glycation End Products, Advanced - metabolism
- Bone and Bones - metabolism
- Collagen - metabolism
- Find related publications in this database (Keywords)
- advanced glycation end-products
- bone quality
- collagen deformation
- cortical bone
- diabetes mellitus