Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Winter, R; Hasiba-Pappas, SK; Tuca, AC; Zrim, R; Nischwitz, S; Popp, D; Lumenta, DB; Girsch, W; Kamolz, LP.
Autologous Fat and Platelet-Rich Plasma Injections in Trapeziometacarpal Osteoarthritis: A Systematic Review and Meta-Analysis.
Plast Reconstr Surg. 2023; 151(1):119-131
Doi: 10.1097/PRS.0000000000009789
Web of Science
PubMed
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Winter Raimund
- Co-authors Med Uni Graz
- Girsch Werner
- Kamolz Lars-Peter
- Lumenta David Benjamin
- Nischwitz Sebastian
- Popp Daniel
- Tuca Alexandru
- Zrim Robert
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- Abstract:
- BACKGROUND: For the treatment of carpometacarpal arthritis of the thumb, various therapies are used. Infiltration therapy with autologous substances such as platelet-rich plasma and autologous fat have recently gained increasing attention because of beneficial pain-reducing effects in arthritis and the associated regenerative potential. However, the extent of clinical evidence in this area and how well autologous substances work in terms of pain reduction and improvements in hand function remain unclear. METHODS: A systematic review and meta-analysis were conducted to evaluate the current evidence and to provide more insight into pain reduction and improvement in hand function after infiltration of autologous substances. The authors identified 11 clinical trials, of which we included eight in the meta-analysis. RESULTS: Autologous substances achieved a good and long-lasting pain reduction, which may also be accompanied by corresponding improvement in hand function. Autologous substances appear to be more effective than corticoid infiltrations. The infiltration of autologous fat seems to be particularly promising in more advanced stages of carpometacarpal arthritis of the thumb. Our meta-analysis showed a mean pain reduction of 2.4 to 3 in visual analogue scale score and a reduction of 18 to 19 points in the Disabilities of the Arm, Shoulder, and Hand questionnaire after infiltration with autologous substances. CONCLUSION: Both platelet-rich plasma and autologous fat infiltration offer an efficient and long-lasting, minimally invasive therapy option in the treatment of carpometacarpal arthritis of the thumb.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Osteoarthritis - surgery
- Thumb - surgery
- Plastic Surgery Procedures - administration & dosage
- Pain - surgery
- Platelet-Rich Plasma - administration & dosage
- Carpometacarpal Joints - surgery