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SHR Neuro Cancer Cardio Lipid Metab Microb

Avdili, A; Rohrhofer, L; Auer, M; Bernecker, C; Schlenke, P; Dorn, I.
Generation of the human erythroblast-derived iPSC line UBTi001-A
STEM CELL RES. 2022; 64: 102910 Doi: 10.1016/j.scr.2022.102910
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Leading authors Med Uni Graz: Avdili Afrim
Co-authors Med Uni Graz: Auer Martina; Bernecker Claudia; Dorn Isabel; Rohrhofer Lisa; Schlenke Peter
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Abstract:: We performed reprogramming of human erythroblasts derived from CD34+ hematopoietic stem / progenitor cells of a healthy donor. CD34+ cells were differen-tiated in-vitro into a pure population of CD36+ erythroblasts and nucleofected with four episomal plasmids expressing SOX2, OCT3/4, KLF4, LIN28, L-MYC and TP53-shRNA. The established iPSC line showed normal karyotype. Pluripotency was confirmed by expression of pluripotency markers and in-vitro differentiation into tissues of all three germ layers. The UBTi001-A iPSC line might provide an attractive source for developmental research on human hematopoiesis and erythropoiesis.