Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

Direkt zur Navigaton springen.
Direkt zum Inhalt springen.

Navigation/Suche

Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid Stoffw Microb

Hiltebrand, LB; Kaiser, HA; Niedhart, DJ; Pestel, G; Kurz, A.
Subcutaneous oxygen pressure in spontaneously breathing lean and obese volunteers: A pilot study
OBES SURG. 2008; 18(1): 77-83. Doi: 10.1007/s11695-007-9313-x
Web of Science PubMed FullText FullText_MUG

Co-Autor*innen der Med Uni Graz: Kurz Andrea
Altmetrics:
Dimensions Citations:
Plum Analytics:
Scite (citation analytics):
Abstract:: Background Oxidative killing is the primary defense against surgical pathogens; risk of infection is inversely related to tissue oxygenation. Subcutaneous tissue oxygenation in obese patients is significantly less than in lean patients during general anesthesia. However, it remains unknown whether reduced intraoperative tissue oxygenation in obese patients results from obesity per se or from a combination of anesthesia and surgery. In a pilot study, we tested the hypothesis that tissue oxygenation is reduced in spontaneously breathing, unanesthetized obese volunteers. Methods Seven lean volunteers with a body mass index (BMI) of 22 +/- 2 kg/m(2) were compared to seven volunteers with a BMI of 46 4 kg/m(2). Volunteers were subjected to the following oxygen challenges: (1) room air; (2) 2 l/min oxygen via nasal prongs, (3) 6 l/min oxygen through a rebreathing face mask; (4) oxygen as needed to achieve an arterial oxygen pressure (arterial PO2) of 200 mmHg; and (5) oxygen as needed to achieve an arterial PO2 Of 300 mmHg. The oxygen challenges were randomized. Arterial PO2 was measured with a continuous intraarterial blood gas analyzer (Paratrend 7); deltoid subcutaneous tissue oxygenation was measured with a polarographic microoxygen sensor (Licox). Results Subcutaneous tissue oxygenation was similar in lean and obese volunteers: (1) room air, 52 +/- 10 vs 58 +/- 8 mmHg; (2) 2 l/min, 77 +/- 25 vs 79 +/- 24 mmHg; (3) 6 l/min, 125 +/- 43 vs 121 +/- 25 mmHg; (4) arterial PO2=200 mmHg, 115 +/- 42 vs 144 +/- 23 mmHg; (5) arterial PO2=300 mmHg, 145 +/- 41 vs 154 +/- 32 mmHg. Conclusion In this pilot study, we could not identify significant differences in deltoid subcutaneous tissue oxygen pressure between lean and morbidly obese volunteers.
Find related publications in this database (Keywords): subcutaneous oxygen pressure; spontaneous breathing; obesity; tissue oxygenation; volunteers