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SHR Neuro Cancer Cardio Lipid Metab Microb

Kimberger, O; Arnberger, M; Brandt, S; Plock, J; Sigurdsson, GH; Kurz, A; Hiltebrand, L.
Goal-directed Colloid Administration Improves the Microcirculation of Healthy and Perianastomotic Colon
ANESTHESIOLOGY. 2009; 110(3): 496-504. Doi: 10.1097/ALN.0b013e31819841f6
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Co-authors Med Uni Graz: Kurz Andrea
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Abstract:: Background: The aim of this study was to compare the effects of goal-directed colloid fluid therapy with goal-directed crystalloid and restricted crystalloid fluid therapy on healthy and perianastomotic colon tissue in a pig model of colon anastomosis surgery. Methods: Pigs (n = 27, 9 per group) were anesthetized and mechanically ventilated. A hand-sewn colon anastomosis was performed. The animals; were subsequently randomized to one of the following treatments: R-RL group, 3 ml . kg(-1) . h(-1) Ringer lactate (RL); GD-RL group, 3 ml . kg(-1) . h(-1) RL + bolus 250 ml of RL; GD-C group, 3 ml . kg(-1) . h(-1) RL + bolus 250 ml of hydroxyethyl starch (HES 6%, 130/0.4). A fluid bolus was administered when mixed venous oxygen saturation dropped below 60%. Intestinal tissue oxygen tension and microcirculatory blood flow were measured continuously. Results: After 4 h of treatment, tissue oxygen tension in healthy colon increased to 150 +/- 31% in group GD-C versits 123 +/- 40% in group GD-RL versits 94 23% in group R-RL (percent of postoperative baseline values, mean +/- SD; P < 0.01). Similarly perianastoniotic tissue oxygen tension increased to 245 +/- 93% in the GD-C group versus 147 +/- 58% in the GD-RL group and 116 +/- 22% in the R-RL group (P < 0.01). Microcirculatory flow was higher in group GD-C in healthy colon. Conclusions: Goal-directed colloid fluid therapy significantly increased microcirculatory blood flow and tissue oxygen tension in healthy and injured colon compared to goal-directed or restricted crystalloid fluid therapy.