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Selected Publication:
Radner, H; Pummer, K; Lax, S; Wandschneider, G; Höfler, H.
Pituitary hyperplasia after goserelin (LHRH-analogue) therapy.
Neuropathol Appl Neurobiol. 1991; 17(1):75-81
Doi: 10.1111/j.1365-2990.1991.tb00696.x
(- Case Report)
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- Co-authors Med Uni Graz
- Pummer Karl
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- Abstract:
- A 78-year-old male was treated with goserelin (Zoladex) for 16 months for metastasizing prostate carcinoma. This therapy is clinically equivalent to orchidectomy, as the application of the luteinizing hormone-releasing hormone (LHRH)-analogue Zoladex causes suppression of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) by down-regulation of pituitary receptors. Consequently, testicular androgen production is inhibited and testosterone levels are decreased to castration levels. In the present case we found diffuse, partially nodular hyperplasia of growth hormone (GH) and adrenocorticotropin (ACTH) producing cells in the anterior pituitary gland at autopsy. As Zoladex reduces pituitary receptors for releasing hormones (RH), a globally increased hypothalamic secretion of RH might be responsible for the ACTH- and the GH-cell hyperplasia. We cannot exclude that Zoladex may cause not only adenomas in rat pituitary glands as reported previously, but also a (nodular) hyperplasia of the pituitary gland in man.
- Find related publications in this database (using NLM MeSH Indexing)
- Adrenocorticotropic Hormone - biosynthesis
- Aged - biosynthesis
- Buserelin - adverse effects
- Goserelin - adverse effects
- Growth Hormone - biosynthesis
- Humans - biosynthesis
- Hyperplasia - chemically induced
- Immunohistochemistry - chemically induced
- Male - chemically induced
- Neoplasm Metastasis - chemically induced
- Orchiectomy - chemically induced
- Pituitary Gland, Anterior - drug effects
- Prostatic Neoplasms - drug therapy
- Find related publications in this database (Keywords)
- LHRH-Analog
- Pituitary Hyperplasia
- GH
- ACTH
- Prostate Carcinoma