Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Jiang, QL; Kurz, A; Zhang, XB; Liu, L; Yang, DS; Sessler, DI.
Supplemental Intraoperative Oxygen and Long-term Mortality
ANESTHESIOLOGY. 2021; 134(5): 709-721.
Doi: 10.1097/ALN.0000000000003694
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Kurz Andrea
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- Abstract:
- Background: Vihether supplemental oxygen worsens long-term mortality remains unclear, with contradictory trial results. The authors therefore tested the hypothesis that supplemental oxygen (8070 vs. 30%l increases the hazard for long-term mortality. Methods: The authors conducted a post hoc analysis of a large multiple crossover cluster trial in which more than 5,000 colorectal surgeries on 4,088 adults were allocated to receive either 30% or 80% inspired oxygen during general anesthesia. The authors assessed the effect of 80% versus 30% target -inspired oxygen on long-term mortality and calculated Kaplan Meier survival estimates. Analysis was restricted to patients with a home address in Ohio because the authors could obtain reliable vital status information from the Ohio Department of Health (Columbus, Ohio) for them. Results: A total of 3,471 qualifying colorectal surgeries performed in 2,801 patients were analyzed, including 1,753 (51%) surgeries in 1,577 patients given 80% oxygen and 1,718 surgeries in 1,551 patients given 30% oxygen. The observed incidence of death after a median of 3 yr was 13% (234 of 1,753) in the 80% oxygen group and 14% (245 of 1,718) in the 30% oxygen group. The estimated hazard ratio for mortality was 0.94 (95% CI, 0.78 to 1.13; P= 0.493). Conclusions: In this post hoc analysis of a large, controlled trial, supplemental oxygen did not increase postoperative mortality.