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SHR Neuro Cancer Cardio Lipid Metab Microb

Pestel, G; Fukui, K; Hager, H; Kurz, A; Hiltebrand, L.
Effect of Supplemental Oxygen versus Dobutamine Administration on Liver Oxygen Tension in dPP-Guided Normovolemic Pigs
EUR SURG RES. 2009; 42(4): 236-244. Doi: 10.1159/000209223
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Co-authors Med Uni Graz: Kurz Andrea
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Abstract:: Background: Difference in pulse pressure (dPP) confirms adequate intravascular filling as a prerequisite for tissue perfusion. We hypothesized that both oxygen and dobutamine increase liver tissue oxygen tension (ptO(2)). Methods: Eight anesthetized pigs received dPP-guided fluid management. Hepatic pO(2) was measured with Clark-type electrodes placed subcapsularly, and on the liver surface. Pigs received: (1) supplemental oxygen (F-iO2 1.0); (2) dobutamine 2.5 mu g/kg/min, and (3) dobutamine 5 mu g/kg/min. Data were analyzed using repeated-measures ANOVA followed by a Tukey post-test for multiple comparisons. ptO(2) measured subcapsularly and at the liver surface were compared using the Bland-Altman plot. Results: Variation in F-iO2 changed local hepatic tissue ptO(2) [subcapsular measurement: 39 8 12 (F-iO2 0.3), 89 8 35 mm Hg (F-iO2 1.0, p = 0.01 vs. F-iO2 0.3), 44 8 10 mm Hg (FiO2 0.3, p = 0.05 vs. F-iO2 1.0); surface measurement: 52 8 35 (F-iO2 0.3), 112 8 24 mm Hg (FiO2 1.0, p = 0.001 vs. FiO2 0.3), 54 8 24 mm Hg (F-iO2 0.3, p = 0.001 vs. F-iO2 1.0)]. Surface measurements were widely scattered compared to subcapsular measurements (bias: -15 mm Hg, precision: 76.3 mm Hg). Dobutamine did not affect hepatic oxygenation. Conclusion: Supplemental oxygen increased hepatic tissue pO(2) while dobutamine did not. Although less invasive, the use of surface measurements is discouraged. Copyright (c) 2009 S. Karger AG, Basel
Find related publications in this database (Keywords): Dobutamine; Difference in pulse pressure; Liver; Monitoring; Oxygen; Tissue oxygen tension