Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Pestel, G; Fukui, K; Hager, H; Kurz, A; Hiltebrand, L.
Effect of Supplemental Oxygen versus Dobutamine Administration on Liver Oxygen Tension in dPP-Guided Normovolemic Pigs
EUR SURG RES. 2009; 42(4): 236-244.
Doi: 10.1159/000209223
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Kurz Andrea
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- Abstract:
- Background: Difference in pulse pressure (dPP) confirms adequate intravascular filling as a prerequisite for tissue perfusion. We hypothesized that both oxygen and dobutamine increase liver tissue oxygen tension (ptO(2)). Methods: Eight anesthetized pigs received dPP-guided fluid management. Hepatic pO(2) was measured with Clark-type electrodes placed subcapsularly, and on the liver surface. Pigs received: (1) supplemental oxygen (F-iO2 1.0); (2) dobutamine 2.5 mu g/kg/min, and (3) dobutamine 5 mu g/kg/min. Data were analyzed using repeated-measures ANOVA followed by a Tukey post-test for multiple comparisons. ptO(2) measured subcapsularly and at the liver surface were compared using the Bland-Altman plot. Results: Variation in F-iO2 changed local hepatic tissue ptO(2) [subcapsular measurement: 39 8 12 (F-iO2 0.3), 89 8 35 mm Hg (F-iO2 1.0, p = 0.01 vs. F-iO2 0.3), 44 8 10 mm Hg (FiO2 0.3, p = 0.05 vs. F-iO2 1.0); surface measurement: 52 8 35 (F-iO2 0.3), 112 8 24 mm Hg (FiO2 1.0, p = 0.001 vs. FiO2 0.3), 54 8 24 mm Hg (F-iO2 0.3, p = 0.001 vs. F-iO2 1.0)]. Surface measurements were widely scattered compared to subcapsular measurements (bias: -15 mm Hg, precision: 76.3 mm Hg). Dobutamine did not affect hepatic oxygenation. Conclusion: Supplemental oxygen increased hepatic tissue pO(2) while dobutamine did not. Although less invasive, the use of surface measurements is discouraged. Copyright (c) 2009 S. Karger AG, Basel
- Find related publications in this database (Keywords)
- Dobutamine
- Difference in pulse pressure
- Liver
- Monitoring
- Oxygen
- Tissue oxygen tension