Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Schulte, EC; Kondofersky, I; Budde, M; Papiol, S; Senner, F; Schaupp, SK; Reich-Erkelenz, D; Klöhn-Saghatolislam, F; Kalman, JL; Gade, K; Hake, M; Comes, AL; Anderson-Schmidt, H; Adorjan, K; Juckel, G; Schmauß, M; Zimmermann, J; Reimer, J; Wiltfang, J; Reininghaus, EZ; Anghelescu, IG; Konrad, C; Figge, C; von, Hagen, M; Jäger, M; Dietrich, DE; Spitzer, C; Witt, SH; Forstner, AJ; Rietschel, M; Nöthen, MM; Falkai, P; Heilbronner, U; Mueller, NS; Schulze, TG.
A novel longitudinal clustering approach to psychopathology across diagnostic entities in the hospital-based PsyCourse study.
Schizophr Res. 2022; 244: 29-38.
Doi: 10.1016/j.schres.2022.05.001
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Reininghaus Eva
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- Abstract:
- Biological research and clinical management in psychiatry face two major impediments: the high degree of overlap in psychopathology between diagnoses and the inherent heterogeneity with regard to severity. Here, we aim to stratify cases into homogeneous transdiagnostic subgroups using psychometric information with the ultimate aim of identifying individuals with higher risk for severe illness. 397 participants of the PsyCourse study with schizophrenia- or bipolar-spectrum diagnoses were prospectively phenotyped over 18 months. Factor analysis of mixed data of different rating scales and subsequent longitudinal clustering were used to cluster disease trajectories. Five clusters of longitudinal trajectories were identified in the psychopathologic dimensions. Clusters differed significantly with regard to Global Assessment of Functioning, disease course, and-in some cases-diagnosis while there were no significant differences regarding sex, age at baseline or onset, duration of illness, or polygenic burden for schizophrenia. Longitudinal clustering may aid in identifying transdiagnostic homogeneous subgroups of individuals with severe psychiatric disease.
- Find related publications in this database (using NLM MeSH Indexing)
- Bipolar Disorder - diagnosis, epidemiology, psychology
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- Find related publications in this database (Keywords)
- Cluster analysis
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