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Mendoza, LC; Harreiter, J; Desoye, G; Simmons, D; Adelantado, JM; Kautzky-Willer, A; Zawiejska, A; Wender-Ozegowska, E; Lapolla, A; Dalfra, MG; Bertolotto, A; Devlieger, R; Dunne, F; Mathiesen, ER; Damm, P; Andersen, LL; Jensen, DM; Hill, D; van Poppel, MNM; Corcoy, R.
The Weak Relationship between Vitamin D Compounds and Glucose Homeostasis Measures in Pregnant Women with Obesity: An Exploratory Sub-Analysis of the DALI Study
NUTRIENTS. 2022; 14(16): 3256 Doi: 10.3390/nu14163256 [OPEN ACCESS]
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Co-authors Med Uni Graz: Desoye Gernot; Van Poppel Mireille Nicoline Maria
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Abstract:: Studies on the relationship between vitamin D (VitD) and glucose homeostasis usually consider either total VitD or 25OHD3 but not 25OHD2 and epimers. We aimed to evaluate the cross-sectional association of VitD compounds with glucose homeostasis measurements in pregnant women with overweight/obesity participating in the Vitamin D And Lifestyle Intervention for Gestational Diabetes Mellitus Prevention study. Methods: The analysis included 912 women. Inclusion criteria: <20 weeks gestation, body mass index >= 29 kg/m(2) and information on exposure and outcome variables at baseline. Measurements: A 75 g OGTT at <20, 24-28 and 35-37 weeks gestation (except if previous diabetes diagnosis). Exposure variables: 25OHD2, 25OHD3 and C3-epimer. Outcome variables: fasting and post-challenge insulin sensitivity and secretion indices, corresponding disposition indices (DI), plasma glucose at fasting and 1 and 2 h, hyperglycemia in pregnancy (HiP). Statistics: Multivariate regression analyses with adjustment. Results: Baseline VitD sufficiency was 66.3%. Overall, VitD compounds did not show strong associations with any glucose homeostasis measures. 25OHD3 showed direct significant associations with: FPG at <20 and 24-28 weeks (standardized beta coefficient (beta) 0.124, p = 0.030 and 0.111, p = 0.026 respectively), 2 h plasma glucose at 24-28 weeks (beta 0.120, p = 0.018), and insulin sensitivity (1/HOMA-IR, beta 0.127, p = 0.027) at 35-37 weeks; it showed an inverse association with fasting DI (QUCKI*HOMA-beta) at <20 and 24-28 weeks (beta -0.124, p = 0.045 and beta -0.148, p = 0.004 respectively). 25OHD2 showed direct associations with post-challenge insulin sensitivity (Matsuda, beta 0.149, p = 0.048) at 24-28 weeks) and post-challenge DI (Matsuda*Stumvoll phase 1) at 24-28 and 35-37 weeks (beta 0.168, p = 0.030, beta 0.239, p = 0.006). No significant association with C3-epimer was observed at any time period. Conclusions: In these women with average baseline VitD in sufficiency range, VitD compounds did not show clear beneficial associations with glucose homeostasis measures.
Find related publications in this database (Keywords): vitamin D compounds; 25OHD2; 25OHD3; C3-epimer; glucose homeostasis; pregnancy; obesity