Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Graier, T; Weger, W; Jonak, C; Sator, P; Zikeli, C; Prillinger, K; Sassmann, C; Gruber, B; Saxinger, W; Ratzinger, G; Painsi, C; Mlynek, A; Häring, N; Sadoghi, B; Trattner, H; Müllegger, R; Quehenberger, F; Salmhofer, W; Wolf, P.
Real-world effectiveness of anti-interleukin-23 antibodies in chronic plaque-type psoriasis of patients from the Austrian Psoriasis Registry (PsoRA).
Sci Rep. 2022; 12(1): 15078
Doi: 10.1038/s41598-022-18790-9
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- Führende Autor*innen der Med Uni Graz
- Graier Thomas
- Co-Autor*innen der Med Uni Graz
- Quehenberger Franz
- Sadoghi Birgit
- Salmhofer Wolfgang
- Weger Wolfgang
- Wolf Peter
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- Abstract:
- With the introduction of the latest class of biologic drugs targeting interleukin (IL)-23p19, three new, highly effective drugs can be used for the treatment of chronic plaque psoriasis. However, poorer skin improvement as well as higher rates of serious adverse events have been reported for patients under real-world conditions (outside clinical trials). This accounts especially for patients who have already been treated with biologic drugs. We therefore aimed to determine effectiveness and safety of IL-23p19 inhibitors in real-world patients by analysing data from the Psoriasis Registry Austria (PsoRA) in this observational, retrospective, multicentre cohort study. Data for 197 patients (52.3% biologic-non-naïve), who were treated with anti-IL-23p19 antibodies (127 guselkumab, 55 risankizumab and 15 tildrakizumab) for at least 3 months, were eligible for analysis. In general, biologic-non-naïve patients displayed a less favourable response to anti-IL-23 treatment as compared to biologic-naïve patients. However, after correction for previous biologic exposure, few differences in PASI improvement were detected among biologic-naïve and -non-naïve patients treated with different IL-23p19 inhibitors. This indicates that treatment effectiveness is not related to the class of the previously administered therapy in biologic-non-naïve patients. Therefore, IL-23p19 inhibitors represent a promising treatment alternative for patients who have not responded to previous biologics. However, as with other biologic agents (including IL-17 inhibitors), we did not observe an entirely satisfactory treatment response (i.e. PASI < 3 and/or PASI 75) to anti-IL-23 treatment in one out of four to five patients. Adverse events (mainly non-severe infections) were observed in 23 (11.7%) patients with no major differences regarding the administered IL-23 inhibitor or previous biologic exposure.
- Find related publications in this database (using NLM MeSH Indexing)
- Austria - epidemiology
- Biological Products - therapeutic use
- Cohort Studies - administration & dosage
- Graft vs Host Disease - drug therapy
- Humans - administration & dosage
- Interleukin-23 - administration & dosage
- Psoriasis - drug therapy
- Registries - administration & dosage
- Retrospective Studies - administration & dosage
- Severity of Illness Index - administration & dosage
- Treatment Outcome - administration & dosage