Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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SHR Neuro Krebs Kardio Lipid Stoffw Microb
Matzhold, EM; Körmöczi, GF; Banfi, C; Schönbacher, M; Drexler-Helmberg, C; Steinmetz, I; Berghold, A; Schlenke, P; Wagner, GE; Stoisser, A; Kleinhappl, B; Mayr, WR; Wagner, T.
Lower Levels of ABO Anti-A and Anti-B of IgM, IgG and IgA Isotypes in the Serum but Not the Saliva of COVID-19 Convalescents.
J CLIN MED. 2022; 11(15):
Doi: 10.3390/jcm11154513
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- Führende Autor*innen der Med Uni Graz
- Matzhold Eva-Maria
- Co-Autor*innen der Med Uni Graz
- Banfi Chiara
- Berghold Andrea
- Kleinhappl Barbara
- Schlenke Peter
- Steinmetz Ivo
- Wagner Thomas
- Wagner-Lichtenegger Gabriel
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- Abstract:
- Individuals with ABO type O, naturally possessing anti-A and anti-B antibodies in their serum, are underrepresented among patients infected with SARS-CoV-2 compared with healthy controls. The ABO antibodies might play a role in the viral transmission. Therefore, we aimed to quantify anti-A/anti-B, including their subclasses IgM, IgG and IgA, in the serum and saliva of Caucasians (n = 187) after mild COVID-19 to compare them with individuals who had never been infected with SARS-CoV-2. Two samples were collected within two months after the diagnosis (median days: 44) and two months later. ABO antibodies were determined by flow cytometry. Additionally, total IgA in saliva and antibodies specific to SARS-CoV-2 were tested by ELISA. COVID-19 convalescents had significantly lower levels of anti-A/anti-B IgM, IgG and IgA in their serum than control subjects (p < 0.001). Interestingly, no significant differences were observed in saliva. ABO antibody levels remained stable over the period considered. No relation of ABO to the level of SARS-CoV-2-specific antibodies was observed. Total IgA was lower in convalescents than in controls (p = 0.038). Whereas ABO antibodies in the saliva may not contribute to the pathogenesis of COVID-19, individual pre-existing high serum concentrations of anti-A/anti-B may have a protective effect against SARS-CoV-2 infection.
- Find related publications in this database (Keywords)
- SARS-CoV-2
- COVID-19
- ABO blood group
- ABO antibodies
- immune system
- immunoglobulin A
- saliva