Medizinische Universität Graz - Research portal
Selected Publication:
Yarosh, DB; O'Connor, A; Alas, L; Potten, C; Wolf, P.
Photoprotection by topical DNA repair enzymes: molecular correlates of clinical studies.
Photochem Photobiol. 1999; 69(2):136-140
Doi: 10.1111/j.1751-1097.1999.tb03265.x
Web of Science
PubMed
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- Co-authors Med Uni Graz
- Wolf Peter
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- Abstract:
- A new approach to photoprotection is to repair DNA damage after UV exposure. This can be accomplished by delivery of a DNA repair enzyme with specificity to UV-induced cyclobutane pyrimidine dimers into skin by means of specially engineered liposomes. Treatment of DNA-repair-deficient xeroderma pigmentosum patients or skin cancer patients with T4N5 liposome lotion containing such DNA repair liposomes increases the removal of DNA damage in the first few hours after treatment. In these studies, a DNA repair effect was observed in some patients treated with heat-inactivated enzyme. Unexpectedly, it was discovered that the heat-inactivated T4 endonuclease V enzyme refolds and recovers enzymatic activity. These studies demonstrate that measurements of molecular changes induced by biological drugs are useful adjuvants to clinical studies.
- Find related publications in this database (using NLM MeSH Indexing)
- Administration, Topical -
- Animals -
- DNA Repair -
- Deoxyribonuclease (Pyrimidine Dimer) -
- Drug Carriers -
- Endodeoxyribonucleases - administration and dosage
- Liposomes - administration and dosage
- Ointments - administration and dosage
- Protein Folding - administration and dosage
- Skin - drug effects
- Skin Neoplasms - drug therapy
- Ultraviolet Rays - drug therapy
- Viral Proteins - drug therapy
- Xeroderma Pigmentosum - drug therapy