Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Andreou, D; Boldt, H; Werner, M; Hamann, C; Pink, D; Tunn, PU.
Sentinel node biopsy in soft tissue sarcoma subtypes with a high propensity for regional lymphatic spread--results of a large prospective trial.
Ann Oncol. 2013; 24(5): 1400-5.
Doi: 10.1093/annonc/mds650
Web of Science
PubMed
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- Leading authors Med Uni Graz
- Andreou Dimosthenis
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- Abstract:
- BACKGROUND: The role of sentinel lymph node biopsy (SLNB) in soft tissue sarcoma patients has yet to be determined. We sought to evaluate the role of SLNB in the treatment of patients with clear cell sarcoma (CCS), synovial sarcoma (SS), epithelioid sarcoma (ES) and rhabdomyosarcoma (RMS). PATIENTS AND METHODS: Sixty-two consecutive patients without history of regional lymphatic spread or evidence of distant metastases underwent SLNB. RESULTS: Positive sentinel nodes were identified in 2 out of 42 patients with SS and in 6 out of 12 patients with CCS. Only two CCS patients had further metastatic nodes in regional dissection. Both of these patients, along with another CCS patient, developed distant metastases and ultimately died of disease. The remaining three CCS patients are disease-free in follow-up. One patient with SS and another with ES developed regional lymph node metastases following a negative SLNB, while a further patient with RMS developed distant metastases followed by a local recurrence with regional metastases shortly after. CONCLUSIONS: SLNB is an important diagnostic tool for patients with CCS, who appear to have a high rate of clinically occult regional lymph node metastases at diagnosis. For SS patients, SLNB appears to be of very little relevance.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent - administration & dosage
- Adult - administration & dosage
- Aged - administration & dosage
- Child - administration & dosage
- Female - administration & dosage
- Humans - administration & dosage
- Lymphatic Metastasis - diagnosis
- Male - administration & dosage
- Middle Aged - administration & dosage
- Prospective Studies - administration & dosage
- Rhabdomyosarcoma - mortality, secondary
- Sarcoma, Clear Cell - mortality, secondary
- Sarcoma, Synovial - mortality, secondary
- Sentinel Lymph Node Biopsy - administration & dosage
- Soft Tissue Neoplasms - mortality
- Young Adult - administration & dosage
- Find related publications in this database (Keywords)
- clear cell sarcoma
- epithelioid sarcoma
- lymph node metastases
- rhabdomyosarcoma
- sentinel node biopsy
- synovial sarcoma