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SHR Neuro Cancer Cardio Lipid Metab Microb
Andreou, D; Werner, M; Pink, D; Traub, F; Schuler, M; Gosheger, G; Jobke, B; Reichardt, P; Tunn, PU.
Prognostic relevance of the mitotic count and the amount of viable tumour after neoadjuvant chemotherapy for primary, localised, high-grade soft tissue sarcoma.
Br J Cancer. 2015; 112(3): 455-60.
Doi: 10.1038/bjc.2014.635
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- Leading authors Med Uni Graz
- Andreou Dimosthenis
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- Abstract:
- BACKGROUND: We sought to examine whether mitotic count (MC) and the amount of viable tumour (VT) following neoadjuvant systemic chemotherapy (SC) for primary, localised, high-grade soft tissue sarcoma (STS) correlate with prognosis. METHODS: Retrospective analysis of 57 patients who underwent SC involving a combination of an anthracycline and an alkylating agent, followed by surgical resection between 2001 and 2011. RESULTS: The amount of VT after chemotherapy was significantly associated with disease-specific survival (DSS) and event-free survival (EFS). Patients with <10% VT had a DSS of 94% at 5 years, compared with 61% for patients with ⩾10% VT (P=0.033); EFS was 75%, compared with 48% (P=0.030). Patients with an MC of ⩾20/10 high power fields (HPF) after chemotherapy had a significantly lower DSS (33% vs 84% at 5 years, P<0.001) and EFS (40% vs 63% at 5 years, P=0.019) than patients with an MC of <20/10 HPF. CONCLUSIONS: The MC and the amount of VT after neoadjuvant therapy for primary, localised, high-grade STS appear to correlate with prognosis. If these results are validated prospectively, then they could provide a rational for the design of neoadjuvant treatment modification/escalation studies, analogue to the EURAMOS-1 trial for bone sarcomas.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent - administration & dosage
- Adult - administration & dosage
- Aged - administration & dosage
- Anthracyclines - administration & dosage
- Antineoplastic Agents - therapeutic use
- Antineoplastic Agents, Alkylating - administration & dosage
- Cell Survival - drug effects
- Disease-Free Survival - administration & dosage
- Female - administration & dosage
- Humans - administration & dosage
- Male - administration & dosage
- Middle Aged - administration & dosage
- Mitotic Index - administration & dosage
- Neoadjuvant Therapy - administration & dosage
- Neoplasm Grading - administration & dosage
- Neoplasm, Residual - administration & dosage
- Predictive Value of Tests - administration & dosage
- Prognosis - administration & dosage
- Retrospective Studies - administration & dosage
- Sarcoma - mortality, pathology, therapy
- Soft Tissue Neoplasms - mortality, pathology, therapy
- Young Adult - administration & dosage
- Find related publications in this database (Keywords)
- soft tissue sarcoma
- viable tumour
- mitotic count
- response assessment
- neoadjuvant treatment