Medizinische Universität Graz - Research portal
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SHR Neuro Cancer Cardio Lipid Metab Microb
Eichler, M; Hentschel, L; Singer, S; Hornemann, B; Hohenberger, P; Kasper, B; Andreou, D; Pink, D; Jakob, J; Arndt, K; Kirchberg, J; Richter, S; Bornhäuser, M; Schmitt, J; Schuler, MK.
Distress in soft-tissue sarcoma and gastrointestinal stromal tumours patients-Results of a German multicentre observational study (PROSa).
Psychooncology. 2022; 31(10):1700-1710
Doi: 10.1002/pon.6009
Web of Science
PubMed
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- Co-authors Med Uni Graz
- Andreou Dimosthenis
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- Abstract:
- OBJECTIVE: Soft tissue sarcomas (STS) and gastrointestinal stromal tumours (GIST) are a group of rare malignant tumours with a high and heterogenous disease burden. As evidence is scarce, we analysed the prevalence of increased emotional distress and identified distress-associated factors in these patients. METHODS: The PROSa-study (Burden and medical care of sarcoma) was conducted between 2017 and 2020 in 39 study centres. Cross-sectional data from adult STS and GIST patients were analysed. Distress was measured with the Patient Health Questionnaire (PHQ-4). The relation of socioeconomic and clinical factors with distress was explored in adjusted logistic regression models. RESULTS: Among 897 patients, 17% reported elevated anxiety and 19% reported depression. Unemployed patients (odds ratio [OR] 6.6; 95% CI 2.9-15.0), and those with a disability pension (OR 3.1; 95% CI 1.9-5.0) were more likely to experience distress compared to employed patients. Also, patients with a disability pass had higher odds of increased distress than those without (OR 1.8; 95% CI 1.2-2.7). Lowest distress was observed in patients 2 to <5 years and ≥5 years after diagnosis (comparison: <6 months) (OR 0.4; 95% CI 0.2-0.6) and (0.3; 95% CI 0.2-0.6). Patients with thoracic STS (vs. lower limbs) had twice the odds to experience distress (OR 2.0; 95% CI 1.1-3.6). Distress was seen almost twice as often in patients with progressive disease (vs. complete remission) (OR 1.7; 95% CI 1.1-2.8). CONCLUSION: The prevalence of elevated distress in STS and GIST patients is high. In unemployed patients, in those with a disability pension and in newly diagnosed patients a noticeable increase was observed. Clinicians should be aware of these factors and consider the social aspects of the disease.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult - administration & dosage
- Anxiety - epidemiology
- Cross-Sectional Studies - administration & dosage
- Gastrointestinal Stromal Tumors - epidemiology
- Humans - administration & dosage
- Sarcoma - epidemiology, therapy
- Soft Tissue Neoplasms - administration & dosage
- Find related publications in this database (Keywords)
- anxiety
- cancer
- depression
- emotional distress
- GIST
- oncology
- PHQ-4
- psycho-oncology
- soft tissue sarcoma