Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Tsokos, M; Schalinski, S; Paulsen, F; Sperhake, JP; Püschel, K; Sobottka, I.
Pathology of fatal traumatic and nontraumatic clostridial gas gangrene: a histopathological, immunohistochemical, and ultrastructural study of six autopsy cases.
Int J Legal Med. 2008; 122(1):35-41
Doi: 10.1007/s00414-007-0163-9
(- Case Report)
Web of Science
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- Co-authors Med Uni Graz
- Heinze Sarah
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- Abstract:
- We prospectively investigated six fatal cases of clostridial gas gangrene using autopsy, histology, immunohistochemistry, microbiology, and scanning electron microscopy. The causative pathogen was Clostridium perfringens in four cases, C. sordellii in one case, and a mixed infection with both C. perfringens and C. sordellii in one case. According to the previous medical history and autopsy findings, clostridial infection was related to trauma in three cases. Characterized by extensive tissue necrosis and total absence of an accompanying leukocyte infiltration and tissue inflammatory response, the histopathological picture of clostridial gas gangrene is distinctly different from other bacterial infections. In medicolegal casework, the proof of the source of infection and the portal of entry of the responsible pathogen is not always an easy task, especially in the absence of trauma.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult - administration & dosage
- Aged - administration & dosage
- Aged, 80 and over - administration & dosage
- Arteriosclerosis - complications
- Brain - microbiology, pathology
- Clostridium - isolation & purification, ultrastructure
- Female - administration & dosage
- Forensic Pathology - administration & dosage
- Gas Gangrene - pathology
- Hemorrhage - microbiology, pathology
- Humans - administration & dosage
- Immunohistochemistry - administration & dosage
- Kidney - microbiology, pathology
- Liver - microbiology, pathology
- Lung - microbiology, pathology
- Male - administration & dosage
- Microscopy, Electron, Scanning - administration & dosage
- Middle Aged - administration & dosage
- Muscle, Skeletal - pathology
- Necrosis - microbiology, pathology
- Pancreatitis - complications
- Prospective Studies - administration & dosage
- Skin Diseases, Vesiculobullous - microbiology, pathology
- Spleen - microbiology, pathology
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- Find related publications in this database (Keywords)
- gas gangrene
- Clostridial myonecrosis
- Clostridium perfringens
- autopsy
- forensic pathology