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SHR Neuro Cancer Cardio Lipid Metab Microb
Ransmayr, L; Fuchs, A; Ransmayr-Tepser, S; Kommenda, R; Kögl, M; Schwingenschuh, P; Fellner, F; Guger, M; Eggers, C; Darkow, R; Mangesius, S; Ransmayr, G.
Differences in aphasia syndromes between progressive supranuclear palsy-Richardson's syndrome, behavioral variant frontotemporal dementia and Alzheimer's dementia.
J NEURAL TRANSM. 2022; 129(8): 1039-1048.
Doi: 10.1007/s00702-022-02524-2
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- Co-authors Med Uni Graz
- Kögl Mariella Waltraud
- Schwingenschuh Petra
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- Abstract:
- Language impairments, hallmarks of speech/language variant progressive supranuclear palsy, also occur in Richardson's syndrome (PSP-RS). Impaired communication may interfere with daily activities. Therefore, assessment of language functions is crucial. It is uncertain whether the Aachen Aphasia Test (AAT) is practicable in PSP-RS, behavioral variant frontotemporal dementia (bvFTD) and Alzheimer's dementia (AD) and language deficits differ in these disorders. 28 PSP-RS, 24 AD, and 24 bvFTD patients were investigated using the AAT and the CERAD-Plus battery. 16-25% of all patients failed in AAT subtests for various reasons. The AAT syndrome algorithm diagnosed amnestic aphasia in 5 (23%) PSP-RS, 7 (36%) bvFTD and 6 (30%) AD patients, Broca aphasia in 1 PSP-RS and 1 bvFTD patient, Wernicke aphasia in 1 bvFTD and 3 (15%) AD patients. However, aphasic symptoms resembled non-fluent primary progressive aphasia in 14 PSP-RS patients. In up to 46% of PSP-RS patients, 61% of bvFTD and 64% of AD patients significant impairments were found in the AAT subtests spontaneous speech, written language, naming, language repetition, language comprehension and the Token subtest. The CERAD-Plus subtest semantic fluency revealed significant impairment in 81% of PSP-RS, 61% of bvFTD, 44% of AD patients, the phonemic fluency subtest in 31, 40 and 31%, respectively. In contrast to bvFTD and AD, severity of language impairment did not correlate with cognitive decline in PSP-RS. In summary, the patterns of aphasia differ between the diagnoses. Local frontal language networks might be impaired in PSP-RS, whereas in AD and bvFTD, more widespread neuropathology might underly language impairment.
- Find related publications in this database (using NLM MeSH Indexing)
- Alzheimer Disease - complications, diagnosis
- Aphasia - etiology
- Frontotemporal Dementia - complications
- Humans - administration & dosage
- Language Development Disorders - administration & dosage
- Neuropsychological Tests - administration & dosage
- Supranuclear Palsy, Progressive - complications, diagnosis
- Find related publications in this database (Keywords)
- Progressive supranuclear palsy
- Behavioral variant frontotemporal dementia
- Alzheimer's dementia
- Non-fluent agrammatic primary progressive aphasia
- Cognitive impairment