Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Bosch, P; Dejaco, C; Schmidt, WA; Schlüter, KD; Pregartner, G; Schäfer, VS.
Association of ultrasound-confirmed axillary artery vasculitis and clinical outcomes in giant cell arteritis.
Semin Arthritis Rheum. 2022; 56:152051
Doi: 10.1016/j.semarthrit.2022.152051
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Bosch Philipp
- Dejaco Christian
- Co-Autor*innen der Med Uni Graz
- Pregartner Gudrun
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- Abstract:
- OBJECTIVES: The aim of this observational study was to compare clinical outcomes including glucocorticoid treatment and relapses between giant cell arteritis (GCA) patients with (axGCA) and without axillary artery involvement (non-axGCA). METHODS: Axillary artery ultrasound was performed in 101 GCA patients at multiple time points. Patients with signs of vasculitis of the axillary arteries at baseline were compared to patients without signs of axillary artery involvement. Cumulative GC doses and relapse rates were calculated as well as survival curves to compare the time until GC discontinuation and occurrence of the first clinical relapse. A linear mixed model was used to assess the effect of a clinical relapse on the intima media thickness (IMT) in axGCA patients. RESULTS: Sixty-seven patients were classified as axGCA, 34 as non-axGCA patients. Compared with non-axGCA, axGCA patients yielded a higher (albeit not significant) median time until GC discontinuation (42 months (95% CI: 33-84) vs 30 months (95% CI: 21-42), p=0.060) and median cumulative GC dose (6801mg (range 1748-34169) vs 5633mg (range: 2553-19967), p=0.051). Time until the first relapse (axGCA: 12 months (95% CI: 8-42) vs non-axGCA: 13.5 months (95% CI: 6-27), p=0522) and relapse rates (2 (range: 0-16) vs 1 (range: 0-13), p=0.67) were similar in both groups. Relapses resulted in an increase of the IMT by 0.18mm (95% CI: 0.07-0.30, p=0.003). CONCLUSION: Patients with axGCA have a trend towards longer treatment duration and higher GC requirements as compared to non-axGCA patients. A relapse leads to an increase of the IMT by 0.18mm.
- Find related publications in this database (using NLM MeSH Indexing)
- Axillary Artery - diagnostic imaging
- Carotid Intima-Media Thickness - administration & dosage
- Giant Cell Arteritis - diagnostic imaging, drug therapy
- Glucocorticoids - therapeutic use
- Humans - administration & dosage
- Recurrence - administration & dosage
- Find related publications in this database (Keywords)
- Giant cell arteritis
- Ultrasound
- Imaging
- Large vessel vasculitis
- Glucocorticoids
- Relapse