Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Hasiba-Pappas, SK; Tuca, AC; Luze, H; Nischwitz, SP; Zrim, R; Geißler, JCJ; Lumenta, DB; Kamolz, LP; Winter, R.
Platelet-Rich Plasma in Plastic Surgery: A Systematic Review.
Transfus Med Hemother. 2022; 49(3):129-142
Doi: 10.1159/000524353
[OPEN ACCESS]
PubMed
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- Führende Autor*innen der Med Uni Graz
- Winter Raimund
- Co-Autor*innen der Med Uni Graz
- Geißler Judith Christine Julie
- Kamolz Lars-Peter
- Lumenta David Benjamin
- Luze Hanna
- Nischwitz Sebastian
- Tuca Alexandru
- Zrim Robert
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- Abstract:
- Introduction: Platelet-rich plasma (PRP) is gaining popularity and is applied in a variety of clinical settings. This review aims to present and evaluate available evidence regarding the use of PRP in various applications in plastic surgery. Methods: PubMed, Web of Science, Medline, and Embase were searched using predefined MeSH terms to identify studies concerning the application of PRP alone or in combination with fat grafting for plastic surgery. The search was limited to articles in English or German. Animal studies, in vitro studies, case reports, and case series were excluded. Results: Of 50 studies included in this review, eleven studies used PRP for reconstruction or wound treatment, eleven for cosmetic procedures, four for hand surgery, two for burn injuries, five for craniofacial disorders, and 17 as an adjuvant to fat grafting. Individual study characteristics were summarized. Considerable variation in preparation protocols and treatment strategies were observed. Even though several beneficial effects of PRP therapy were described, significance was not always demonstrated, and some studies yielded conflicting results. Efficacy of PRP was not universally proven in every field of application. Conclusion: This study presents an overview of current PRP treatment options and outcomes in plastic surgery. PRP may be beneficial for some indications explored in this review; however, currently available data are insufficient and systematic evaluation is limited due to high heterogeneity in PRP preparation and treatment regimens. Further randomized controlled trials employing standardized protocols are warranted.