Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Buergy, D; Würschmidt, F; Gkika, E; Hörner-Rieber, J; Knippen, S; Gerum, S; Balermpas, P; Henkenberens, C; Voglhuber, T; Kornhuber, C; Barczyk, S; Röper, B; Rashid, A; Blanck, O; Wittig, A; Herold, HU; Brunner, TB; Klement, RJ; Kahl, KH; Ciernik, IF; Ottinger, A; Izaguirre, V; Putz, F; König, L; Hoffmann, M; Combs, SE; Guckenberger, M; Boda-Heggemann, J.
Stereotactic or conformal radiotherapy for adrenal metastases: Patient characteristics and outcomes in a multicenter analysis.
Int J Cancer. 2021; 149(2): 358-370.
Doi: 10.1002/ijc.33546
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Brunner Thomas Baptist
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- Abstract:
- To report outcome (freedom from local progression [FFLP], overall survival [OS] and toxicity) after stereotactic, palliative or highly conformal fractionated (>12) radiotherapy (SBRT, Pall-RT, 3DCRT/IMRT) for adrenal metastases in a retrospective multicenter cohort within the framework of the German Society for Radiation Oncology (DEGRO). Adrenal metastases treated with SBRT (≤12 fractions, biologically effective dose [BED10] ≥ 50 Gy), 3DCRT/IMRT (>12 fractions, BED10 ≥ 50 Gy) or Pall-RT (BED10 < 50 Gy) were eligible for this analysis. In addition to unadjusted FFLP (Kaplan-Meier/log-rank), we calculated the competing-risk-adjusted local recurrence rate (CRA-LRR). Three hundred twenty-six patients with 366 metastases were included by 21 centers (median follow-up: 11.7 months). Treatment was SBRT, 3DCRT/IMRT and Pall-RT in 260, 27 and 79 cases, respectively. Most frequent primary tumors were non-small-cell lung cancer (NSCLC; 52.5%), SCLC (16.3%) and melanoma (6.7%). Unadjusted FFLP was higher after SBRT vs Pall-RT (P = .026) while numerical differences in CRA-LRR between groups did not reach statistical significance (1-year CRA-LRR: 13.8%, 17.4% and 27.7%). OS was longer after SBRT vs other groups (P < .05) and increased in patients with locally controlled metastases in a landmark analysis (P < .0001). Toxicity was mostly mild; notably, four cases of adrenal insufficiency occurred, two of which were likely caused by immunotherapy or tumor progression. Radiotherapy for adrenal metastases was associated with a mild toxicity profile in all groups and a favorable 1-year CRA-LRR after SBRT or 3DCRT/IMRT. One-year FFLP was associated with longer OS. Dose-response analyses for the dataset are underway.
- Find related publications in this database (using NLM MeSH Indexing)
- Adrenal Gland Neoplasms - radiotherapy, secondary
- Aged - administration & dosage
- Aged, 80 and over - administration & dosage
- Carcinoma, Non-Small-Cell Lung - radiotherapy
- Databases, Factual - administration & dosage
- Female - administration & dosage
- Humans - administration & dosage
- Lung Neoplasms - radiotherapy
- Male - administration & dosage
- Middle Aged - administration & dosage
- Palliative Care - administration & dosage
- Radiosurgery - administration & dosage
- Radiotherapy Dosage - administration & dosage
- Radiotherapy, Conformal - administration & dosage
- Retrospective Studies - administration & dosage
- Small Cell Lung Carcinoma - radiotherapy
- Survival Analysis - administration & dosage
- Treatment Outcome - administration & dosage
- Find related publications in this database (Keywords)
- adrenal
- oligometastases
- outcome
- patterns of care
- SBRT