Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Holzer-Petsche, U; Moser, RL.
Pharmacological evidence for the release of galanin from rat stomach.
NEUROPEPTIDES 1993 25: 47-50.
Doi: 10.1016/0143-4179(93)90067-K
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Holzer Ulrike
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- The neuropeptide galanin has been shown to occur in nerve fibres in the circular muscle layer of the rat stomach. The present experiments aimed at demonstrating a functional correlate for this observation by testing the motor effects of galanin on circular strips of the rat gastric corpus in vitro. Exogenous galanin elicited only small contractions of the smooth muscle which were dose-related but did not show a clear sigmoid dose-response relationship. These responses were resistant to atropine plus guanethidine or TTX. When the muscle strips were electrically stimulated, they showed pronounced rebound contractions after the end of the stimulus. These rebound contractions were significantly reduced by either desensitizing the strips to galanin or by addition of spantide. It is concluded that galanin is released from the myenteric plexus in the stomach and acts to modulate gastric contractions either postsynaptically or by modifying the release of tachykinins.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Female -
- Galanin -
- Male -
- Muscle Contraction - drug effects
- Muscle, Smooth - drug effects
- Myenteric Plexus - secretion
- Peptides - antagonists and inhibitors
- Rats - antagonists and inhibitors
- Rats, Sprague-Dawley - antagonists and inhibitors
- Research Support, Non-U.S. Gov't - antagonists and inhibitors
- Stomach - drug effects
- Substance P - analogs and derivatives